Trimidox-Induced Apoptosis Is Mediated Through Induction of p53 in NALM-6 Cells

スポンサーリンク

概要

• 論文の詳細を見る

• We examined the effect of trimidox-induced apoptosis involvement of p53 in the NALM-6 cell line of acute lymphoblastic leukemia. Trimidox has been shown to increase the induction of p53. Phosphorylation of p53 protein at Ser-15 and Ser-20 residues was activated earlier than the obvious increase in p53 expression. Pifithrin-α, a p53 inhibitor, significantly prevented trimidox-induced apoptotic characteristics, as detected by nuclear morphological observation and DNA fragmentation. Trimidox-induced apoptosis was enhanced or attenuated by transfection with wild-type or dominant-negative p53 containing expression vectors, respectively. These results indicate that one of the induction mechanisms of apoptosis by trimidox is the mediated augmentation of p53.

• 社団法人 日本薬理学会の論文
• 2008-03-20

著者

• SATOH Susumu

  Department of Pharmacology and Pharmacotherapy, Nihon Pharmaceutical University

• ISHIKAWA Masaaki

  Department of Pharmacology and Toxicology, Cancer Research Institute, Tohoku Pharmaceutical Universi

• KANNO Syu-ichi

  Department of Clinical Pharmacotherapeutics, Tohoku Pharmaceutical University

• OSANAI Yuu

  Department of Clinical Pharmacotherapeutics, Tohoku Pharmaceutical University

• KURAUCHI Kaori

  Department of Clinical Pharmacotherapeutics, Tohoku Pharmaceutical University

• UJIBE Mayuko

  Department of Clinical Pharmacotherapeutics, Tohoku Pharmaceutical University

• Osanai Yuu

  Department Of Clinical Pharmacotherapeutics Tohoku Pharmaceutical University

• Ujibe Mayuko

  Department Of Clinical Pharmacotherapeutics Tohoku Pharmaceutical University

• Kanno Syu-ichi

  Department Of Clinical Pharmacotherapeutics Tohoku Pharmaceutical University

• Kanno Syu-ichi

  東北薬科大学癌研究所

• Kimura Katsuhiko

  Department Of Clinical Pharmacotherapeutics Tohoku Pharmaceutical University

• Satoh S

  Department Of Pharmacology And Pharmacotherapy Nihon Pharmaceutical University

• Satoh Susumu

  Nagasaki Institute Of Applied Science

• Kanno Syu-ichi

  東北薬科大学 薬物治療学教室

• OHTAKE Takaharu

  Department of Clinical Pharmacotherapeutics, Tohoku Pharmaceutical University

• UWAI Koji

  Department of Pharmaceutics, Tohoku Pharmaceutical University

• TAKESHITA Mituhiro

  Department of Pharmaceutics, Tohoku Pharmaceutical University

• Kanno Syu-ichi

  Department Of Pharmacology And Toxicology Cancer Research Institute Tohoku Pharmaceutical University

• Ishikawa Masaaki

  Department Of Clinical Pharmacotherapeutics Tohoku Pharmaceutical University

• Ishikawa Masaaki

  Department Of Pharmacology And Toxicology Cancer Research Institute Tohoku Pharmaceutical University

• Ishikawa Masaaki

  Department Of Pharmacology And Toxicology Cancer Research Institute Tohoku College Of Pharmacy

• Uwai Kohji

  Department Of Pharmacology Tohoku Pharmaceutical University

• Uwai Koji

  Department Of Pharmaceutics Tohoku Pharmaceutical University

• Koiwai Kimiko

  Department Of Pharmacology And Toxicology Cancer Research Institute Tohoku Pharmaceutical University

• Ohtake Takaharu

  Department Of Clinical Pharmacotherapeutics Tohoku Pharmaceutical University

• Satoh Susumu

  Department Of Neurosurgery Yamagata Prefectural Central Hospital

• Ishikawa Masaaki

  Dep. Of Clinical Pharmacotheraputics Tohoku Pharmaceutical Univ. Jpn

• Takeshita Mitsuhiro

  Department Of Pharmacology Tohoku Pharmaceutical University

関連論文

• Costunolide-Induced Apoptosis Is Caused by Receptor-Mediated Pathway and Inhibition of Telomerase Activity in NALM-6 Cells(Pharmacology)
• Intrathecally Administered D-Cycloserine Produces Nociceptive Behavior Through the Activation of N-Methyl-D-aspartate Receptor Ion-Channel Complex Acting on the Glycine Recognition Site
• Anti-inflammatory Effect of Propolis through Inhibition of Nitric Oxide Production on Carrageenin-Induced Mouse Paw Edema(Pharmacology)
• Early Gastric Cancer Associated with Synchronous Liver Metastasis and Portal Tumorous Embolism : Report of a Case
• Stress/Strain Controlling Parameter of Cracked Plate with Mechanical Heterogeneity
• Effect of Mechanical Heterogeneity on Fracture Toughness Evaluation of Steel Welds
• A Proposal of Generalized COD Criterion and Its Application to Welds
• Stresses-Strains and Fracture Behavior of 9% Ni Steel Weldments
• Crack Tip Plastic Deformation of Notched Plates with Mechanical Heterogeneity
• A Proposal on 3 Point Bending COD Test Method for Welded Joint of 9% Ni Steel
• Trimidox-Induced Apoptosis Is Mediated Through Induction of p53 in NALM-6 Cells
• Inhibitory Effect of Propolis on the Growth of Human Leukemia U937 (Toxicology)
• Resistance to Ara-C Up-Regulates the Activation of NF-κB, Telomerase Activity and Fas Expression in NALM-6 Cells(Pharmacology)
• Circumvention of Acquired Resistance to Doxorubicin in K562 Human Leukemia Cells by Oxatomide
• Reversal of Vinblastine Resistance in Human Leukemic Cells by Haloperidol and Dihydrohaloperidol
• Mechanism of Resistance to Oxidative Stress in Doxorubicin Resistant Cells
• Potentiation of Acetaminophen Hepatotoxicity by Doxapram in Mouse Primary Cultured Hepatocytes
• Reversal of Multidrug Resistance in Human Leukemia K562 by Tamolarizine, a Novel Calcium Antagonist
• Role of Endogenous Endotoxin on Tumor Necrosis Factor-Hypersensitivity Caused by D-Galactosamine Challenge
• Reversal of Acquired Resistance to Doxorubicin in K562 Human Leukemia Cells by Astemizole
• Characterization of Hydrogen Peroxide-Induced Apoptosis in Mouse Primary Cultured Hepatocytes
• Exposure to Hydrogen Peroxide Induces Cell Death via Apoptosis in Primary Cultured Mouse Hepatocytes
• Potentiation of Acetaminophen Hepatotoxicity and Mortality by Doxapram in Mice
• Thalidomide Promotes the Release of Tumor Necrosis Factor-α (TNF-α) and Lethality by Lipopolysaccharide in Mice
• Effects of Antitumor Activity and Protection of Shock Symptoms by a Traditional Chinese Medicine (Sho-Saiko-To) in Recombinant Human Tumor Necrosis Factor Administered Mice
• Inhibition of Hepatic Mixed-Function Oxidase Enzymes in Mice by Acute and Chronic Treatment with Selenium
• Inhibition of Hepatic Drug Biotransformation by Carrageenan-Induced Inflammation in the Rat : Effect of Sex Hormone Alterations
• Effect of Carrageenan-Induced Inflammation on the Induction of Hepatic Microsomal Enzymes by Phenobarbital and Benzo [α] pyrene in Male Rats
• Hepatic Drug Metabolizing Activity in Rats with Carrageenan-Induced Inflammation
• Inhibitory Effect of Trimidox on Lipopolysaccharide-Induced Nitric Oxide Production in RAW 264.7 Macrophages
• Preventive Effect of Trimidox on Oxidative Stress in U937 Cell Line(Pharmacology)
• Melatonin Protects on Toxicity by Acetaminophen But Not on Pharmacological Effects in Mice(Pharmacology)
• Octylcaffeate Induced Apoptosis in Human Leukemia U937 Cells(Biopharmacy)
• Inhibitory Effects of Naringenin on Tumor Growth in Human Cancer Cell Lines and Sarcoma S-180-Implanted Mice(Pharmacology)
• Effects of Naringin on Hydrogen Peroxide-Induced Cytotoxicity and Apoptosis in P388 Cells
• Inhibitory Effect of Octylcaffeate on Lipopolysaccharide-Induced Nitric Oxide Production in Macrophages
• Diethyldithiocarbamate-Induced Cytotoxicity and Apoptosis in Leukemia Cell Lines
• 日本人における Denaturing HPLC を用いたCYP2S1遺伝子の新規SNPスクリーニング
• Stability of Magnesium Oxide Products in Single-dose Packages
• Genetic Variations in the HGPRT, ITPA, IMPDH1, IMPDH2, and GMPS Genes in Japanese Individuals
• Comparison of Stereotactic Aspiration, Craniotomy, and Conservative Treatment for Putaminal Hemorrhage
• Cerebral Blood Flow in Patients with Putaminal Hemorrhage after Stereotactic Aspiration or Conservative Treatment
• Changes in Cerebral Hemodynamics after Extracranial-intracranial Bypass
• A Case of Idiopathic Intussusception in an Adult
• A Case of Primary Carcinoma of the Vermiform Appendix in an Early Stage
• The number of species occurring in a sample of a biotic community and its connections with species - abundance relationship and spatial distribution
• Delayed Recovery of Effector Memory CD4+ T Cells by Highly Active Antiretroviral Therapy in a Patient with HIV-1 Infection
• EFFECTS OF TESTOSTERONE AND ESTRADIOL ON PROSTAGLANDIN E SYNTHESIS BY RAT KIDNEY MEDULLA
• Successful Simultaneous Operation of Concomitant Early Gastric Cancer, Transverse Colon Cancer, and a Common Iliac Artery Aneurysm
• EFFECTS OF PHENYLEPHRINE ON RENIN AND PROSTAGLANDIN E2 RELEASE IN ANESTHETIZED DOGS
• Functional Characterization of Genetic Polymorphisms Identified in the Promoter Region of the Xanthine Oxidase Gene
• Kinetics of 6-Thioxanthine Metabolism by Allelic Variants of Xanthine Oxidase
• FURTHER STUDIES ON THE POTENTIATING EFFECT OF LITHIUM CHLORIDE ON METHAMPHETAMINE-INDUCED STEREOTYPY IN MICE
• The regeneration of pioneer tree species under browsing pressure of Sika deer in an evergreen oak forest
• HYPOTENSIVE EFFECT OF CAPTOPRIL IN RELATION TO PLASMA RENIN ACTIVITY IN ANESTHETIZED RATS
• Freeze-Shut Conditions of Water or Solution Flow in an Isothermally Cooled Parallel Plate Channel
• On the weak formulation of the stochastic obstacle problems
• Cilnidipine Attenuates Renal Nerve Stimulation-Induced Renal Vasoconstriction and Antinatriuresis in Anesthetized Dogs
• ABSENCE OF A NEURALLY-MEDIATED PROCESS IN SALIVATION AND VASODILATION CAUSED BY McN-A-343 IN THE DOG SUBMAXILLARY GLAND
• DIFFERENT MODE OF ACTION BETWEEN NOREPINEPHRINE AND PHENYLEPHRINE ON PROSTAGLANDIN SYNTHESIS BY DOG RENAL INNER MEDULLARY SLICES
• EFFECT OF CAPTOPRIL, A CONVERTING ENZYME INHIBITOR ON RENAL VASCULAR RESISTANCE IN PENTOBARBITAL ANESTHETIZED DOGS
• STIMULATION OF RENIN RELEASE FROM DOG RENAL CORTICAL SLICES WITH L-ISOPROTERENOL AND DIBUTYRYL CYCLIC ADENOSINE 3, 5-MONOPHOSPHATE
• DIFFERENCES AMONG DIPYRIDAMOLE, CARBOCHROMEN AND LIDOFLAZINE IN RESPONSES OF THE CORONARY AND THE RENAL ARTERIES
• SECRETORY AND VASCULAR RESPONSE TO VARIOUS BIOGENIC AND FOREIGN SUBSTANCES OF THE PERFUSED CANINE PANCREAS
• A study comparing ultrasound images of tongue movements between open bite children and normal children to the early mixed dentition period
• FURTHER STUDIES ON THE SUPPRESSING EFFECT OF ISOPROTERENOL ON THE IMMOBILITY-REDUCING ACTION OF DESIPRAMINE IN THE FORCED SWIMMING TEST
• A three-dimensional study on the morphological variation of the upper permanent central incisor and the first molars : Relationship with congenital missing of the adjacent teeth
• Hypotensive effect of captopril, an angiotensin converting enzyme inhibitor in pentobarbital anesthetized dogs.
• Effect of forskolin on prostaglandin productions in isolated dog renal arteries.
• Inhibitory effect of cilazaprilat on norepinephrine release induced by renal nerve stimulation in anesthetized dogs.
• Effect of sizofilan, an immunomodulator, on hepatic microsomal mixed-function oxidase activities in rats.
• The deleterious effect of buthionine sulfoximine, a glutathione-depleting agent, on the cisplatin toxicity in mice.
• Injurious effect of buthionine sulfoximine, an inhibitor of glutathione biosynthesis, on the lethality and urotoxicity of cyclophosphamide in mice.
• Exacerbation of Doxorubicin Toxicity by Chlorpromazine in Male ddY Mice.
• Endotoxin- and Inflammation-Induced Depression of the Hepatic Drug Metabolism in Rats.

もっと見る 閉じる

スポンサーリンク