Effects of Naringin on Hydrogen Peroxide-Induced Cytotoxicity and Apoptosis in P388 Cells
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概要
- 論文の詳細を見る
Flavonoids are widely recognized as naturally occurring antioxidants. Naringin (NG) is one of the flavonoid components in citrus fruits such as grapefruit. Hydrogen peroxide (H2O2) causes cytotoxicity through oxidative stress and apoptosis. In this paper, we examined the effects of NG on H2O2-induced cytotoxicity and apoptosis in mouse leukemia P388 cells. Cytotoxicity was determined by mitochondrial activity (MTT assay). Apoptosis and DNA damage were analyzed by measuring chromatin condensation and Comet assay (alkaline single cell gel electrophoresis), respectively. H2O2-induced cytotoxicity was significantly attenuated by NG or the reduced form of glutathione (GSH), a typical intracellular antioxidant. NG suppressed chromatin condensation and DNA damage induced by H2O2. These results indicate that NG from natural products is a useful drug having antioxidant and anti-apoptopic properties.
- 社団法人 日本薬理学会の論文
- 2003-06-01
著者
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ISHIKAWA Masaaki
Department of Pharmacology and Toxicology, Cancer Research Institute, Tohoku Pharmaceutical Universi
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Kanno Syu-ichi
Department Of Clinical Pharmacotherapeutics Tohoku Pharmaceutical University
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Kanno Syu-ichi
東北薬科大学癌研究所
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Kanno Syu-ichi
東北薬科大学 薬物治療学教室
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Kanno Syu-ichi
Department Of Pharmacology And Toxicology Cancer Research Institute Tohoku Pharmaceutical University
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SHOUJI Ai
Department of Clinical Pharmacotherapeutics, Tohoku Pharmaceutical University
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KANNNO syu-ichi
Department of Pharmacology and Toxicology. Cancer Research Institute, Tohoku Pharmaceutical Universi
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ASOU Keiko
Department of Pharmacology and Toxicology. Cancer Research Institute, Tohoku Pharmaceutical Universi
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Ishikawa Masaaki
Department Of Clinical Pharmacotherapeutics Tohoku Pharmaceutical University
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Ishikawa Masaaki
Department Of Pharmacology And Toxicology Cancer Research Institute Tohoku Pharmaceutical University
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Ishikawa Masaaki
Department Of Pharmacology And Toxicology Cancer Research Institute Tohoku College Of Pharmacy
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Kanno Syuichi
Department Of Clinical Pharmacotherapeutics Tohoku Pharmaceutical University
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Shouji Ai
Department Of Clinical Pharmacotherapeutics Tohoku Pharmaceutical University
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Asou Keiko
Department Of Pharmacology And Toxicology. Cancer Research Institute Tohoku Pharmaceutical Universit
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Ishikawa Masaaki
Dep. Of Clinical Pharmacotheraputics Tohoku Pharmaceutical Univ. Jpn
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