Potentiation of Acetaminophen Hepatotoxicity and Mortality by Doxapram in Mice

概要

論文の詳細を見る
Whether a single dose of doxapram (DOP) can modulate the acteu toxicity and the hepatotoxicity induced by acetaminphen (AA) was examined. Pretreatment with DOP (40 mg/kg, i.p.) 30 min prior to the administration of AA dose-dependently potentiated the lethality of AA in both native mice and mice fasted for 18 h, and the potentiating activity was greater in fasted mice than in native mice. The hepatotoxicity of AA was assessed by plasma transaminases activity (glutamyl oxaloacetic transaminase, GOT; glutamyl pyruvic transaminase. GPT) and the amount of plasma lipid peroxides at 6,12,18,24,36 and 48 h after the administration of AA and histopathological examination of liver sections at 24 h after the administration of AA. DOP (40 mg/kg, i.p.) did not increase the plasma transaminase activity or the lipid peroxides level significantly, whereas AA administration to DOP-treated animals produced eariler maximal elevation of transaminase and lipid peroxide values compared to AA alone. These findings indicate that mortality and hepatotoxicity of AA is potentiated by DOP in mice.
社団法人日本薬学会の論文
1998-09-15