Hot Water Extract of Bark of Nikko Maple (Acer nikoense) Induces Apoptosis in Leukemia Cells
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概要
- 論文の詳細を見る
In screening for antitumor constituents in traditional crude drugs, we used three cultured cell lines : mouse leukemia P388 cells, doxorubicin-resistant P388 cells and leczyme (catalytic lectin)-resistant P388 cells. The hot water extract (HWE) of the bark of Nikko maple (Acer nikoense) showed concentration-dependent inhibitory effects on the growth of these three cell lines. DNA fragmentation and morphological changes, accompanied by condensed and fragmented nuclei, were observed in the leukemina cell lines cultured with HWE of the bark of Nikko maple. Treatment with this HWE increased the expression of sialylated glycoconjuagtes on the apoptotic cells. These results suggest that HWE induces cell death via apoptosis in vitro.
- 公益社団法人日本薬学会の論文
- 1999-04-15
著者
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Ogawa Y
Institute Of Molecular Biomembrane And Glycobiology Tohoku Pharmaceutical University
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TAKAYANAGI Yoshio
Cancer Research Institute, Tohoku Pharmaceutical University
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NITTA Kazuo
Cancer Research Institute, Tohoku Pharmaceutical University
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Nitta K
Institute Of Molecular Biomembrane And Glycobiology Tohoku Pharmaceutical University
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Nitta Kazuo
Moa Health Science Foundation
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Nitta Kazuo
Cancer Research Institute Tohoku Pharmaceutical University
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HOSONO Masahiro
Institute of Molecular Biomembrane and Glycobiology, Tohoku Pharmaceutical University
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Takayanagi Y
Department Of Pharmacology And Toxicology Cancer Research Institute Tohoku Pharmaceutical University
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Takayanagi Yoshio
Cancer Research Institute Tohoku Pharmaceutical University
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OGAWA Yukiko
Cancer Research Institute, Tohoku College of Pharmaceutical Sciences
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NEGISHI Fukiko
Cancer Research Institute, Tohoku College of Pharmaceutical Sciences
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TAKAHASHI Toshiaki
Cancer Research Institute, Tohoku College of Pharmaceutical Sciences
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ITO Aya
Cancer Research Institute, Tohoku College of Pharmaceutical Sciences
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HOSONO Masahiro
Cancer Research Institute, Tohoku College of Pharmaceutical Sciences
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Ito Aya
Cancer Research Institute Tohoku College Of Pharmaceutical Sciences
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Negishi Fukiko
Cancer Research Institute Tohoku College Of Pharmaceutical Sciences
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Hosono Masahiro
Institute Of Molecular Biomembrane And Glycobiology Tohoku Pharmaceutical University
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Takahashi Toshiaki
Cancer Research Institute Tohoku College Of Pharmaceutical Sciences
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