Potentiation of Pirarubicin Activity in Multidrug Resistant Cells by Rifampicin
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概要
- 論文の詳細を見る
The effect of the anti-tuberculosis drug rifampicin on pirarubicin activity was investigated in multidrug-resistant cells overexpressing P-glycoprotein. Rifampicin increased the sensitivity of pirarubicin to anthracycline-resistant mouse leukemic P388 cells and significantly enhanced the cytotoxicity and intracellular accumulation of pirarubicin in resistant cells, but had no effect in parent cells. By contrast, two other rifamycins, rifamycin B and SV, had no effect on pirarubicin accumulation in resistant cells. Rifampicin also enhanced pirarubicin-induced apoptosis and G_2/M blockade on the cell cycle in resistant cells. These results show that rifampicin enhances the cytotoxic action of pirarubicin in resistant cells, at least partly via the inhibition of cellular pirarubicin efflux.
- 社団法人日本薬学会の論文
- 1997-12-15
著者
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TAKAYANAGI Motoaki
Department of Pathophysiology, Tohoku Pharmaceutical University
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Sasaki K
Dep. Of Pharmacology And Toxicology Cancer Res. Inst. Tohoku Pharmaceutical Univ.
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Takayanagi M
Department Of Pathophysiology Tohoku Pharmaceutical University
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Takayanagi Motoaki
Department Of Pharmacology And Toxicology Cancer Research Institute Tohoku Pharmaceutical University
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Takayanagi Motoaki
Cancer Research Institute Tohoku Pharmaceutical University
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FURUSAWA Shinobu
Department of pharmacology and Toxicology, Cancer Research Institute, Tohoku Pharmaceutical Universi
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SASAKI Ken-ichi
Department of pharmacology and Toxicology, Cancer Research Institute, Tohoku Pharmaceutical Universi
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TAKAYANAGI Yoshio
Department of Pharmacology and Toxicology, Cancer Research Institite, Tohoku Phamaceutical Universit
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NAKANO Shinya
Department of Pharmacology and Toxicology, Cancer Research Institute, Tohoku Pharmaceutical Universi
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FURUSAWA Shinobu
Cancer Research Institute, Tohoku Pharmaceutical University
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WU Jianghong
Department of Pharmacology and Toxicology, Cancer Research Institute, Tohoku College of Pharmacy
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Ishikawa Masaaki
東北薬科大学癌研究所
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Takayanagi Y
Department Of Pharmacology And Toxicology Cancer Research Institute Tohoku Pharmaceutical University
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Wu Jianghong
Department Of Pharmacology And Toxicology Cancer Research Institute Tohoku College Of Pharmacy
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Kanno Shu-ichi
Department Of Pharmacology And Toxicology Cancer Research Institute Tohoku Pharmaceutical University
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SASAKI Kenichi
Cancer Research Institute, Tohoku College of Pharmacy
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Sasaki Ken-ichi
Department Of Pharmacology And Toxicology Cancer Research Institute Tohoku Pharmaceutical University
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Nakano S
Department Of Pharmacology And Toxicology Cancer Research Institute Tohoku Pharmaceutical University
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Sasaki Ken-ichi
Department Of Pathology Sapporo Medical University School Of Medicine
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Sasaki Ken-ichi
Department Of Chemistry Faculty Of Science Hiroshima University
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