Exacerbation of Doxorubicin Toxicity by Chlorpromazine in Male ddY Mice.
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概要
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We examined whether chlorpromazine (CPZ) modulates the lethality of doxorubicin (DOX, 12 mg/kg, i.p.) in mice treated with CPZ (6 mg/kg, i.p.) 1 hr before administration of DOX. Pretreatment with CPZ produced: 1) earlier deaths and 2) an increase in the number of deaths, compared to the controls. Potentiation of the bone marrow toxicity of DOX by CPZ was also reflected in the drug lethality towards the animals.
- 公益社団法人 日本薬理学会の論文
著者
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TAKAYANAGI Yoshio
Department of Pharmacology and Toxicology, Cancer Research Institite, Tohoku Phamaceutical Universit
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Ishikawa Masaaki
Department Of Clinical Pharmacotherapeutics Tohoku Pharmaceutical University
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Sasaki Ken-ichi
Department Of Chemistry Faculty Of Science Hiroshima University
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