Octylcaffeate Induced Apoptosis in Human Leukemia U937 Cells(Biopharmacy)
スポンサーリンク
概要
- 論文の詳細を見る
We found that octylcaffeate, a semisynthetic caffeic acid derivative, strongly inhibited the growth of human histiolytic lymphoma U937 cells in a dose- and time-dependent manner via apoptosis. Octylcaffeate induced the fragmentation of DNA into multiples of 180bp (an apoptotic DNA ladder) and condensation of chromatin, and increased the percentage of hypodiploid cells detected with a flow cytometer. DNA fragmentation induced by octylcaffeate was inhibited by pretreatment with Z-DEVD-FMK and Z-Asp-CH_2D-CB, an inhibitor of caspase, clearly showing that the mode of cell death is apoptotic. These findings suggest that the cytotoxicity of octylcaffeate involves the induction of apoptosis.
- 公益社団法人日本薬学会の論文
- 2005-12-01
著者
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ISHIKAWA Masaaki
Department of Pharmacology and Toxicology, Cancer Research Institute, Tohoku Pharmaceutical Universi
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OSANAI Yuu
Department of Clinical Pharmacotherapeutics, Tohoku Pharmaceutical University
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UJIBE Mayuko
Department of Clinical Pharmacotherapeutics, Tohoku Pharmaceutical University
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Osanai Yuu
Department Of Clinical Pharmacotherapeutics Tohoku Pharmaceutical University
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Ujibe Mayuko
Department Of Clinical Pharmacotherapeutics Tohoku Pharmaceutical University
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Kanno Syu-ichi
Department Of Clinical Pharmacotherapeutics Tohoku Pharmaceutical University
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Kanno Syu-ichi
東北薬科大学癌研究所
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Kimura Katsuhiko
Department Of Clinical Pharmacotherapeutics Tohoku Pharmaceutical University
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Kanno Syu-ichi
東北薬科大学 薬物治療学教室
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OHTAKE Takaharu
Department of Clinical Pharmacotherapeutics, Tohoku Pharmaceutical University
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KOIWAI Kimiko
Department of Pharmacology and Toxicology, Cancer Research Institute, Tohoku College of Pharmacy
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Kanno Syu-ichi
Department Of Pharmacology And Toxicology Cancer Research Institute Tohoku Pharmaceutical University
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KANNO Syuichi
Department of Pharmacology and Toxicology, Cancer Research Institute, Tohoku Pharmaceutical Universi
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OSANAI Yu
Department of Pharmacology and Toxicology, Cancer Research Institute, Tohoku Pharmaceutical Universi
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UWAI Kohji
Tohoku Employees' Pension Welfare Hospital
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TAKESHITA Mitsuhiro
Tohoku Employees' Pension Welfare Hospital
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Ishikawa Masaaki
Department Of Clinical Pharmacotherapeutics Tohoku Pharmaceutical University
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Ishikawa Masaaki
Department Of Pharmacology And Toxicology Cancer Research Institute Tohoku Pharmaceutical University
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Ishikawa Masaaki
Department Of Pharmacology And Toxicology Cancer Research Institute Tohoku College Of Pharmacy
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Kanno Syuichi
Department Of Clinical Pharmacotherapeutics Tohoku Pharmaceutical University
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Uwai Kohji
Department Of Pharmacology Tohoku Pharmaceutical University
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Koiwai Kimiko
Department Of Pharmacology And Toxicology Cancer Research Institute Tohoku Pharmaceutical University
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Ohtake Takaharu
Department Of Clinical Pharmacotherapeutics Tohoku Pharmaceutical University
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Ishikawa Masaaki
Dep. Of Clinical Pharmacotheraputics Tohoku Pharmaceutical Univ. Jpn
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Koiwai Kimiko
Department Of Clinical Pharmacotherapeutics Tohoku Pharmaceutical University
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Takeshita Mitsuhiro
Department Of Pharmacology Tohoku Pharmaceutical University
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Takeshita Mitsuhiro
Tohoku College Of Pharmacy
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Kimura Katsuhiko
Department Of Biology Fauculty Of Science Osaka City University
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