Reversal of Multidrug Resistance in Human Leukemia K562 by Tamolarizine, a Novel Calcium Antagonist
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概要
- 論文の詳細を見る
A new type of organic Ca2+ channel blocker, tamolarizine, was examined for its reversing effect on multidrug-resistant tumor cells.Tamolarizine synergistically potentiated the cytotoxicity of doxorubicin for doxorubicin-resistant K562 cells(K562/DXR)at a concentration of 0.1-10μM, but had hardly any synergistic effects in the parental cell line(K562)at the same concentration.Moreover, tamolarizine inhibits the P-glycoprotein pump-efflux activity in a dose-related manner and reduces the expression of the immunoreactive P-glycoprotein in K562/DXR cells as evaluated by cytofluorimetric assay.These results indicate that tamolarizine reverses the multidrug-resistance phenotype through direct interaction with P-gylcoprotein.
- 社団法人 日本薬理学会の論文
- 2000-03-01
著者
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ISHIKAWA Masaaki
Department of Pharmacology and Toxicology, Cancer Research Institute, Tohoku Pharmaceutical Universi
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TAKAYANAGI Motoaki
Department of Pathophysiology, Tohoku Pharmaceutical University
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Sasaki K
Dep. Of Pharmacology And Toxicology Cancer Res. Inst. Tohoku Pharmaceutical Univ.
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Takayanagi M
Department Of Pathophysiology Tohoku Pharmaceutical University
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Takayanagi Motoaki
Department Of Pharmacology And Toxicology Cancer Research Institute Tohoku Pharmaceutical University
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Takayanagi Motoaki
Cancer Research Institute Tohoku Pharmaceutical University
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FUJITA Ryousuke
Department of pharmacology and Toxicology, Cancer Research Institute, Tohoku Pharmaceutical Universi
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SASAKI Ken-ichi
Department of pharmacology and Toxicology, Cancer Research Institute, Tohoku Pharmaceutical Universi
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TAKAYANAGI Yoshio
Department of Pharmacology and Toxicology, Cancer Research Institite, Tohoku Phamaceutical Universit
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MIYAKE Norihisa
Medical Information Department and Planning & Investigation Department, Nippon Chemiphar Co., Ltd.
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Ishikawa Masaaki
東北薬科大学癌研究所
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Ishikawa Masaaki
Department Of Clinical Pharmacotherapeutics Tohoku Pharmaceutical University
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Ishikawa Masaaki
Department Of Pharmacology And Toxicology Cancer Research Institute Tohoku Pharmaceutical University
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Ishikawa Masaaki
Department Of Pharmacology And Toxicology Cancer Research Institute Tohoku College Of Pharmacy
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Takayanagi Y
Department Of Pharmacology And Toxicology Cancer Research Institute Tohoku Pharmaceutical University
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Kanno Shu-ichi
Department Of Pharmacology And Toxicology Cancer Research Institute Tohoku Pharmaceutical University
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SASAKI Kenichi
Cancer Research Institute, Tohoku College of Pharmacy
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Miyake Norihisa
Medical Information Department And Planning & Investigation Department Nippon Chemiphar Co. Ltd.
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Sasaki Ken-ichi
Department Of Pharmacology And Toxicology Cancer Research Institute Tohoku Pharmaceutical University
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Sasaki Ken-ichi
Department Of Pathology Sapporo Medical University School Of Medicine
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Fujita Ryousuke
Department Of Pharmacology And Toxicology Cancer Research Institute Tohoku Pharmaceutical University
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Sasaki Ken-ichi
Department Of Chemistry Faculty Of Science Hiroshima University
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