Reduction of Cyclophosphamide-Induced Toxicity by Diethyldithiocarbamate and Carbon Disulfide and Its Possible Mechanism

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概要

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• The mechanism of reduction in cyclophosphamide (CPA)-induced toxicity by diethyldithiocarbamate (DTC) and carbon disulfide (CS_2) was examined in relation to CPA metabolism in mice. Pretreatment with DTC (100 mg/kg) or CS_2 (50 mg/kg), p. o. decreased the acute toxicity of CPA. Active metabolites of CPA in the plasma after the administration of CPA (100 or 450 mg/kg, i. p.) was lowered by DTC or CS_2 treatment. The liver microsomal CPA oxidase activity decreased 1 h after the administration of DTC (25-100 mg/kg, p. o.) or CS_2 (12.5-50 mg/kg, p. o.). These results suggested that the reduction of CPA-induced toxicity in mice pretreated with DTC or CS_2 was due to the inhibition of activation of CPA and reduced formation of alkylating metabolites.

• 公益社団法人日本薬学会の論文

著者

• Sasaki K

  Dep. Of Pharmacology And Toxicology Cancer Res. Inst. Tohoku Pharmaceutical Univ.

• FURUSAWA Shinobu

  Cancer Research Institute, Tohoku Pharmaceutical University

• SASAKI Kenichi

  Cancer Research Institute, Tohoku College of Pharmacy

• TAKAYANAGI Giichi

  Cancer Research Institute, Tohoku College of Pharmacy

• Sasaki Kenichi

  Cancer Research Institute Tohoku College Of Pharmacy

• Sasaki Ken-ichi

  Department Of Pharmacology And Toxicology Cancer Research Institute Tohoku Pharmaceutical University

• Furusawa Shinobu

  Cancer Resarch Institute Tohoku College Of Pharmaceutical Sciences

• Furusawa Shinobu

  Cancer Research Institute Tohoku College Of Pharmacy

• Takayanagi Giichi

  Cancer Resarch Institute Tohoku College Of Pharmaceutical Sciences

• Takayanagi Giichi

  Cancer Research Institute Tohoku College Of Pharmacy

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