Reversal of resistance to doxorubicin with cepharanthine in murine P388 leukemia cells.
スポンサーリンク
概要
- 論文の詳細を見る
Cytotoxic effect in vitro and antitumor effect in vivo of doxorubicin (DOX) combined with cepharanthine were investigated on DOX-resistant murine P388 leukemia (P388/R) cells. Cepharanthine was minimally cytotoxic in the cell line, but reversed DOX-resistance in a dose-related manner in P388/R cells. The administration of cepharanthine to mice bearing the P388 leukemia enhanced the antitumor activity of DOX. These results indicate that cepharanthine is an effective agent to reverse DOX-resistant cells.
- 公益社団法人 日本薬理学会の論文
著者
-
Takayanagi Yoshio
Cancer Research Institute Tohoku Pharmaceutical University
-
Sasaki Ken-ichi
Cancer Resarch Institute Tohoku College Of Pharmaceutical Sciences
-
Furusawa Shinobu
Cancer Resarch Institute Tohoku College Of Pharmaceutical Sciences
-
SASAKI Ken-ichi
Cancer Research Institute, Tohoku College of Pharmacy
-
SHIBATA Hironobu
Cancer Research Institute, Tohoku College of Pharmacy
-
FUJIMURA Tsutomu
Cancer Research Institute, Tohoku College of Pharmacy
-
MAEKAWA Itoko
Cancer Research Institute, Tohoku College of Pharmacy
-
KAWAUCHI Hiroaki
Cancer Research Institute, Tohoku College of Pharmacy
-
TAKAYANAGI Yoshio
Cancer Research Institute, Tohoku College of Pharmacy
関連論文
- Role of Endogenous Endotoxin on Tumor Necrosis Factor-Hypersensitivity Caused by D-Galactosamine Challenge
- Effects of Antitumor Activity and Protection of Shock Symptoms by a Traditional Chinese Medicine (Sho-Saiko-To) in Recombinant Human Tumor Necrosis Factor Administered Mice
- Effect of Modification of the Carboxyl Groups of the Sialic Acid Binding Lectin from Bullfrog(Rana catesbeiana)Oocyte on Anti-tumor Activity
- Hot Water Extract of Bark of Nikko Maple (Acer nikoense) Induces Apoptosis in Leukemia Cells
- Apoptotic Cell Death Induced by Physarumin (Hemagglutinin from Myxomycete, Physarum polycephalum)
- Reduction of Cyclophosphamide-Induced Toxicity by Diethyldithiocarbamate and Carbon Disulfide and Its Possible Mechanism
- BIPHASIC EFFECT OF DOXAPRAM ON HYPNOTIC ACTIVITY OF PENTOBARBITAL IN MICE
- Preventive Effects of a Traditional Chinese Medicine (Sho-saiko-to) on Septic Shock Symptoms ; Approached from Heme Metabolic Disorders in Endotoxemia(Pharmacognosy)
- EFFECTS OF CHLORDIAZEPOXIDE, DIAZEPAM AND OXAZEPAM ON THE ANTITUMOR ACTIVITY, THE LETHALITY AND THE BLOOD LEVEL OF ACTIVE METABOLITES OF CYCLOPHOSPHAMIDE AND CYCLOPHOSPHAMIDE OXIDASE ACTIVITY IN MICE
- EFFECT OF DOXAPRAM ON THE ACTION OF OTHER DRUGS AND THE HEPATIC DRUG-METABOLIZING SYSTEM IN MICE
- DRUG INTERACTION OF ANTITUMOR DRUGS III. ANTITUMOR ACTIVITY OF TEGAFUR IN LIPOPOLYSACCHARIDE-TREATED MICE
- Preventive Effects of a Traditional Chinese Medicine(Sho-saiko-to)on Endotoxin-Induced Cytotoxicity and Tumor Necrosis Factor-α Production in J774A.1 Cells(Pharmacognosy)
- EFFECT OF TINORIDINE ON DOXORUBICIN-INDUCED LETHALITY IN MICE
- Effect of lipopolysaccharide (from Escherichia coli) on the hepatic drug-metabolizing activities in successively LPS-treated mice.
- Reversal of resistance to doxorubicin with cepharanthine in murine P388 leukemia cells.
- Effect of buthionine sulfoximine, an inhibitor of glutathione biosynthesis, on the selenium-induced lethality in mice.
- Depression of hepatic microsomal enzyme systems by lentinan in mice.