Effects of Antitumor Activity and Protection of Shock Symptoms by a Traditional Chinese Medicine (Sho-Saiko-To) in Recombinant Human Tumor Necrosis Factor Administered Mice

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概要

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• The effects of a traditional Chinese medicine Sho-saiko-to (Kampo prescription) were investigated on the various metabolic disorders and antitumor activity of recombinant human tumor necrosis factor (rhTNF) administered to mice. The glycogen level in liver of rhTNF (5×10^4 units/mouse, i.v.)-injected mice was markedly lower at 4 h post-intoxication than that in the control, whereas the administration of rhTNF to Sho-saiko-to (500 mg/kg/d, p.o.)-pretreated mice resulted in a greater level of glycogen than that in rhTNF alone-treated mice. In mice pretreated with Sho-saiko-to, the level of fibrinogen 4 h after rhTNF injection markedly increased as compared to that in mice treated with rhTNF alone. We also estimated the NO^-_2 in murine macrophage cell line J774A.1 using mice serum after administration of Sho-saiko-to. Our results clearly demonstrated that J774A.1 cells stimulated with endotoxin (1 μg/ml) and rhTNF (1×10^4 units/ml) can effectively produce nitric oxide (NO), and ascertained the suppressive effect of Sho-saiko-to (500 mg/kg/d, p.o.)-pretreated serum on NO generation by endotoxin/TNF-activated J774A.1 cells. When the cells were incubated with endotoxin/TNF and Sho-saiko-to pretreated serum (10-100 μl), the NO level was significantly lower than that in control serum incubated with endotoxin/TNF alone. The effect of Sho-saiko-to (1 and 10 μg/ml) on in vitro cytotoxicity by rhTNF in Meth-A Sarcoma cells was observed to be in a dose dependent fashion. In addition, there was a remarkable enhancement of antitumor activity of rhTNF by Sho-saiko-to pretreatment in mice. These findings suggest that the Kampo prescription Sho-saiko-to may protect mice from severe shock syndrome by rhTNF, and that it may enhance rhTNF-induced antitumor activity.

• 社団法人日本薬学会の論文
• 1996-11-15

著者

• Sakaguchi Shuhei

  東北薬科大学 第一衛生化学

• Sakaguchi Shuhei

  First Department Of Hygienic Chemistry Tohoku Pharmaceutical University

• Satoh S

  Department Of Pharmacology And Pharmacotherapy Nihon Pharmaceutical University

• Satoh Susumu

  Nagasaki Institute Of Applied Science

• TAKAYANAGI Motoaki

  Department of Pathophysiology, Tohoku Pharmaceutical University

• Sasaki K

  Dep. Of Pharmacology And Toxicology Cancer Res. Inst. Tohoku Pharmaceutical Univ.

• Takayanagi M

  Department Of Pathophysiology Tohoku Pharmaceutical University

• Takayanagi Motoaki

  Department Of Pharmacology And Toxicology Cancer Research Institute Tohoku Pharmaceutical University

• Takayanagi Motoaki

  Cancer Research Institute Tohoku Pharmaceutical University

• FURUSAWA Shinobu

  Cancer Research Institute, Tohoku Pharmaceutical University

• YOKOTA Katsushi

  First Department of Hygienic Chemistry, Tohoku Pharmaceutical University

• SASAKI Ken-ichi

  Cancer Research Institute, Tohoku Pharmaceutical University

• TAKAYANAGI Yoshio

  Cancer Research Institute, Tohoku Pharmaceutical University

• Ishikawa Masaaki

  東北薬科大学癌研究所

• YOKOTA Katsushi

  Department of Environmental Health Science, Tohoku Pharmaceutical University

• Takayanagi Y

  Department Of Pharmacology And Toxicology Cancer Research Institute Tohoku Pharmaceutical University

• Takayanagi Yoshio

  Cancer Research Institute Tohoku Pharmaceutical University

• Kanno Shu-ichi

  Department Of Pharmacology And Toxicology Cancer Research Institute Tohoku Pharmaceutical University

• SASAKI Kenichi

  Cancer Research Institute, Tohoku College of Pharmacy

• Sasaki Ken-ichi

  Department Of Pharmacology And Toxicology Cancer Research Institute Tohoku Pharmaceutical University

• Sasaki Ken-ichi

  Cancer Resarch Institute Tohoku College Of Pharmaceutical Sciences

• Kataoka Yumi

  Department Of Environmental Health Science Tohoku Pharmaceutical University

• Yokota Katsushi

  First Department Of Hygienic Chemistry Tohoku College Of Pharmacy

• Furusawa Shinobu

  Cancer Resarch Institute Tohoku College Of Pharmaceutical Sciences

• Sakaguchi Shuhei

  First Department of Hygienic Chemistry ; Tohoku Pharmaceutical University

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