Influences of Drugs on the Oxygen Uptake Rate and Biosorption of Activated Sludge(Miscellaneous)

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概要

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• To prevent pollution of the water environment by drugs, we evaluated factors affecting the elimination of drugs by inducing reactions between the pharmaceutical chemicals originating from the drugs and activated sludge (AS) in test tubes. Of 30 pharmaceutical chemicals examined, ibuprofen (IBP) as an anti-inflammatory drug most markedly inhibited the oxygen uptake rate (OUR) of AS, and its IC_<50> was 172mg/l. The IBP elimination from the wastewater was due to the significant biosorption by AS and was based on the time-response and dose-response relationships. In the pharmaceutical chemical group (1) (diclofenac Na, ketoprofen, indomethacin, salicylic acid, mefenamic acid, phenylbutazone, chlorpromazine・HCl, furosemide, tolbutamide and warfarin K) showing a relatively significant OUR inhibition (IC_<50>, 200-500mg/l), protein binding (75-99.7%), and the biosorption by AS also tended to be significant. In group (2) (acetaminophen, kanamycin・H_2SO_4, antipyrine, ethenzamide, gentamicin・H_2SO_4, cyclophosphamide・HCl, aminophylline, procainamide・HCl and cimetidine) showing a negligible OUR inhibition (IC_<50>≥2000mg/l), the protein binding was slight (0-74%), and biosorption by AS was also negligible. For the IBP and group (1), AS was pretreated with a certain excessive amount of each pharmaceutical chemical, and the qualitative OUR curves of the AS-synthetic sewage-II after washing showed a significant OUR inhibition immediately after the start of the reaction. Group (2), as well as the control group showed no OUR inhibition. These results suggest that the degree of OUR inhibition of AS by pharmaceutical chemicals is affected by the protein binding and the degree of biosorption. This suggests that pharmaceutical chemicals with a significant protein binding possibility can be eliminated from the wastewater by binding to AS.

• 公益社団法人日本薬学会の論文
• 2006-01-01

著者

• Kumagai Takeshi

  Tohoku Pharmaceutical University

• Kumagai Takeshi

  Department Of Environmental Health Science Tohoku Pharmaceutical University

• Kumagai Takeshi

  東北薬科大学 環境衛生学

• Kumagai T

  Tohoku Pharmaceutical Univ. Sendai Jpn

• YOKOTA Katsushi

  First Department of Hygienic Chemistry, Tohoku Pharmaceutical University

• 蝦名 敬一

  東北薬大・環境衛生

• YOKOTA Katsushi

  Department of Environmental Health Science, Tohoku Pharmaceutical University

• KUMAGAI Takeshi

  First Department of Hygienic Chemistry, Tohoku Pharmaceutical University

• EBINA Keiichi

  First Department of Hygienic Chemistry, Tohoku Pharmaceutical University

• INOUE Tatsuaki

  First Department of Hygienic Chemistry, Tohoku Pharmaceutical University

• MIHARA Yuichi

  Waste Water Treatment Center, Tohoku Pharmaceutical University

• Mihara Yuichi

  Waste Water Treatment Center Tohoku Pharmaceutical University

• Ebina Keiichi

  Department Of Environmental Health Science Tohoku Pharmaceutical University

• Inoue Tatsuaki

  First Department Of Hygienic Chemistry Tohoku Pharmaceutical University

• Kataoka Yumi

  Department Of Environmental Health Science Tohoku Pharmaceutical University

• Yokota Katsushi

  First Department Of Hygienic Chemistry Tohoku College Of Pharmacy

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