A Synthetic Peptide (P-21) Derived from Asp-Hemolysin Inhibits the Induction of Macrophage Proliferation by Oxidized Low-Density Lipoprotein(Microbiology)

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概要

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• Macrophage-derived foam cells play an important role in atherosclerotic lesions. Oxidized low-density lipoprotein (OxLDL) induces macrophage proliferation via the specific uptake of lysophosphatidylcholine (LysoPC) of OxLDL by class A, type I and type II macrophage scavenger receptors. We have previously shown that Asp-hemolysin from Aspergillus fumigatus binds to LysoPC as a typical lipid moiety of OxLDL. This study investigated the effect of the Asp-hemolysin-related peptide (P-21), a synthetic peptide derived from a region of Asp-hemolysin that is rich in positive charges, on macrophage proliferation induced by OxLDL. Mouse peritoneal macrophages were used for proliferation study. OxLDL induced macrophage proliferation in an oxidation time-dependent manner, and P-21 inhibited OxLDL-induced macrophage proliferation in a dose-dependent manner. Furthermore, the binding analysis of P-21 to OxLDL by dissociation-enhanced lanthanide fluorometric immunoassay indicated that P-21 binds to OxLDL. These results indicate that P-21 inhibits the OxLDL-induced macrophage proliferation through binding of P-21 to OxLDL.

• 公益社団法人日本薬学会の論文
• 2005-08-01

著者

• Kumagai Takeshi

  Tohoku Pharmaceutical University

• Kumagai Takeshi

  Department Of Environmental Health Science Tohoku Pharmaceutical University

• Kumagai Takeshi

  東北薬科大学 環境衛生学

• Kumagai T

  Tohoku Pharmaceutical Univ. Sendai Jpn

• YOKOTA Katsushi

  First Department of Hygienic Chemistry, Tohoku Pharmaceutical University

• 蝦名 敬一

  東北薬大・環境衛生

• TSUTSUMI Hiromu

  Department of Environmental Health Science, Tohoku Pharmaceutical University

• YOKOTA Katsushi

  Department of Environmental Health Science, Tohoku Pharmaceutical University

• TSUTSUMI Hiromu

  First Department of Hygienic Chemistry, Tohoku Pharmaceutical University

• KUMAGAI Takeshi

  First Department of Hygienic Chemistry, Tohoku Pharmaceutical University

• EBINA Keiichi

  First Department of Hygienic Chemistry, Tohoku Pharmaceutical University

• OGAWA Norihiro

  First Department of Hygienic Chemistry, Tohoku Pharmaceutical University

• Ebina Keiichi

  Department Of Environmental Health Science Tohoku Pharmaceutical University

• Ogawa Norihiro

  Department Of Environmental Health Science Tohoku Pharmaceutical University

• Kataoka Yumi

  Department Of Environmental Health Science Tohoku Pharmaceutical University

• Yokota Katsushi

  First Department Of Hygienic Chemistry Tohoku College Of Pharmacy

• Tsutsumi Hiromu

  Department Of Environmental Health Science Tohoku Pharmaceutical University

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