Asp-hemolysinのマクロファージ細胞毒性に対する低密度リポタンパク質及びその酸化修飾体の影響

概要

論文の詳細を見る
We examined the effects of human low density lipoprotein(LDL) and oxidized LDL(Ox-LDL) on the cytotoxic activity of Asp-hemolysin from Aspergillus fumigatus Fresenius-Muramatsu strain to mouse peritoneal macrophages (Mφ). The inhibitory effects of LDL and Ox-LDL on the cytotoxic activity of Asp-hemolysin to Mφ increased in a dose-dependent manner, and the effect of Ox-LDL was greater than the inhibitory effect of LDL. Furthermore, the binding of Asp-hemolysin to LDL or Ox-LDL was observed by western blot analysis of the culture medium. These results suggest that the inhibition by LDL or Ox-LDL on the cytotoxic activity of Asp-hemolysin to Mφ was due to the binding of LDL or Ox-LDL to Asp-hemolysin in the culture medium.
社団法人日本薬学会の論文
2001-04-01