血管内皮細胞に対するAsp-hemolysinの細胞毒性とサイトカイン遺伝子発現誘導活性

概要

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We examined the effects of Asp-hemolysin from Aspergillus fumigatus Fresenius-Muramatsu strain on the viability and cytokine gene expression of human umbilical vein endothelial cells(HUVEC). The cell viability of HUVEC was reduced to 50% by 100μg/ml of Asp-hemolysin. However, lower concentration of Asp-hemolysin(<30μg/ml) had no effect on the cell viability. The mRNA expression of such cytokines as tumor necrosis factor-α(TNF-α), interleukin (IL)-1β, IL-6, IL-8 and granulocyte-macrophage colony stimulating factor (GM-CSF) were also observed in HUVEC cultured with 30μg/ml of Asp-hemolysin.
社団法人日本薬学会の論文
2001-04-01