Apolipoprotein B Inhibits the Hemolytic Activity of Asp-Hemolysin from Aspergillus fumigatus

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概要

• 論文の詳細を見る

• We investigated the effect of human blood plasma lipoproteins on the hemolytic activity of Asp-hemolysin. Apolipoprotein B (apoB)-containing lipoproteins, such as low density lipoprotein (LDL) and very low density lipoprotein (VLDL), inhibit the activity of this hemolytic toxin. When Asp-hemolysin (15 μg) was incubated with 100 μg LDL (as protein), the hemolytic activity was inhibited by 90%. When 20 μg apoB was added, the hemolytic activity was almost completely inhibited. Furthermore, similar inhibition was obtained in the filtrates which were separated from the incubation mixture of Asp-hemolysin with LDL or apoB following ultrafiltration through a membrane with a molecular cutoff=100000. The current findings suggest that the inhibition by LDL is due to apoB binding to Asp-hemolysin.

• 公益社団法人日本薬学会の論文
• 1996-04-15

著者

• Kumagai Takeshi

  Tohoku Pharmaceutical University

• Kumagai Takeshi

  Department Of Environmental Health Science Tohoku Pharmaceutical University

• Kumagai Takeshi

  東北薬科大学 環境衛生学

• Kumagai T

  Tohoku Pharmaceutical Univ. Sendai Jpn

• YOKOTA Katsushi

  First Department of Hygienic Chemistry, Tohoku Pharmaceutical University

• 蝦名 敬一

  東北薬大・環境衛生

• YOKOTA Katsushi

  Department of Environmental Health Science, Tohoku Pharmaceutical University

• KUMAGAI Takeshi

  First Department of Hygienic Chemistry, Tohoku Pharmaceutical University

• EBINA Keiichi

  First Department of Hygienic Chemistry, Tohoku Pharmaceutical University

• FUKUCHI Yuji

  Japanese Red Cross Sendai Hospital

• FUKUCHI Yuji

  Pharmacy, Japanese Red Cross Sendai Hospital

• Ebina Keiichi

  Department Of Environmental Health Science Tohoku Pharmaceutical University

• Kataoka Yumi

  Department Of Environmental Health Science Tohoku Pharmaceutical University

• Yokota Katsushi

  First Department Of Hygienic Chemistry Tohoku College Of Pharmacy

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