Apoptotic Cell Death Induced by Physarumin (Hemagglutinin from Myxomycete, Physarum polycephalum)

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概要

• 論文の詳細を見る

• Physarumin, a carbohydrate-binding protein (hemagglutinin or lectin), was isolated from the plasmodium of Physarum polycephalum. Physarumin agglutinated not only several species of erythrocytes but also tumor cells such as AH109A ascites hepatoma cells, sarcoma 180 ascites cells and mouse leukemia P388 cell lines. Physarumin had tumor cell growth -inhibitory activity, and induced the apoptosis of P388 cell lines. Physarumin-induced apoptosis required binding to a 68 kDa counter-receptor on the P388 cell surface. Since the agglutinating and antiproliferative activities of physarumin were inhibited by asialofetuin and thyroglobulin, respectively, it is suggested that physarumin reacts with the galactose moiety of carbohydrate chains of physarumin receptor.

• 公益社団法人日本薬学会の論文
• 1998-03-15

著者

• Ogawa Y

  Institute Of Molecular Biomembrane And Glycobiology Tohoku Pharmaceutical University

• TAKAYANAGI Yoshio

  Cancer Research Institute, Tohoku Pharmaceutical University

• NITTA Kazuo

  Cancer Research Institute, Tohoku Pharmaceutical University

• Nitta K

  Institute Of Molecular Biomembrane And Glycobiology Tohoku Pharmaceutical University

• Nitta Kazuo

  Moa Health Science Foundation

• Nitta Kazuo

  Cancer Research Institute Tohoku Pharmaceutical University

• HOSONO Masahiro

  Institute of Molecular Biomembrane and Glycobiology, Tohoku Pharmaceutical University

• Takayanagi Y

  Department Of Pharmacology And Toxicology Cancer Research Institute Tohoku Pharmaceutical University

• Takayanagi Yoshio

  Cancer Research Institute Tohoku Pharmaceutical University

• OGAWA Yukiko

  Cancer Research Institute, Tohoku College of Pharmaceutical Sciences

• HOSONO Masahiro

  Cancer Research Institute, Tohoku College of Pharmaceutical Sciences

• NUMATA Chifumi

  Cancer Research Institute, Tohoku College of Pharmaceutical Sciences

• YOKOTA Masayoshi

  Department of Health Sciences, Asahikawa College of Hokkaido University of Education

• SUZUKI Takefumi

  Cancer Research Institute, Tohoku College of Pharmaceutical Sciences

• Numata Chifumi

  Cancer Research Institute Tohoku College Of Pharmaceutical Sciences

• Suzuki Takefumi

  Cancer Research Institute Tohoku College Of Pharmaceutical Sciences

• Hosono Masahiro

  Institute Of Molecular Biomembrane And Glycobiology Tohoku Pharmaceutical University

• Yokota Masayoshi

  Department Of Health Sciences Asahikawa College Of Hokkaido University Of Education

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