Alteration of Gene Expression Induced by Silurus asotus Lectin in Burkitt's Lymphoma Cells(Biochemistry)
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概要
- 論文の詳細を見る
Silurus asotus lectin (SAL) is a member of the rhamnose-binding lectin (RBL) family, and recognizes globotriaosylceramide (Gb3) on the cell surface of Burkitt's lymphoma cell lines, such as Raji and Daudi cells. The variation of gene expression in the treatment of both cells with SAL was analyzed using the differential display (DD) method with combination of 16 kinds of arbitary primers and 3 kinds of anchor primers. Treatment of Raji cells with SAL down-regulated mitochondria-associated granulocyte-macropharge colony-stimulating factor (GM-CSF) signaling molecule (Magmas) gene, and up-regulated N-myc downstream regulated gene (NDRG) 3. On the other hand, treatment of Daudi cells with SAL down-regulated Rad50 gene. Since Magmas gene expression was repressed in SAL-treated Raji cells, but did not change in SAL-treated D-threo-1-phenyl-2-decanoylamino-3-morphorino-1-propanol (PDMP)-pretreated Raji cells, it was clear that the expression of Magmas, NDRG3 or Rad50 was regulated by SAL binding to Gb3.
- 公益社団法人日本薬学会の論文
- 2008-05-01
著者
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Nitta K
Institute Of Molecular Biomembrane And Glycobiology Tohoku Pharmaceutical University
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Nitta Kazuo
Moa Health Science Foundation
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KAWANO Tasuku
Institute of Molecular Biomembrane and Glycobiology, Tohoku Pharmaceutical University
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SUGAWARA Shigeki
Institute of Molecular Biomembrane and Glycobiology, Tohoku Pharmaceutical University
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HOSONO Masahiro
Institute of Molecular Biomembrane and Glycobiology, Tohoku Pharmaceutical University
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TATSUTA Takeo
Institute of Molecular Biomembrane and Glycobiology, Tohoku Pharmaceutical University
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Kawano Tasuku
Institute Of Molecular Biomembrane And Glycobiology Tohoku Pharmaceutical University
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Hosono Masahiro
Institute Of Molecular Biomembrane And Glycobiology Tohoku Pharmaceutical University
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Sugawara Shigeki
Institute Of Molecular Biomembrane And Glycobiology Tohoku Pharmaceutical University
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KAWANO Tasuku
Division of Cell Recognition Study, Institute of Molecular Biomembrane and Glycobiolgy, Tohoku Pharm
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SUGAWARA Shigeki
Division of Cell Recognition Study, Institute of Molecular Biomembrane and Glycobiolgy, Tohoku Pharm
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HOSONO Masahiro
Division of Cell Recognition Study, Institute of Molecular Biomembrane and Glycobiolgy, Tohoku Pharm
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TATSUTA Takeo
Division of Cell Recognition Study, Institute of Molecular Biomembrane and Glycobiolgy, Tohoku Pharm
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NITTA Kazuo
Division of Cell Recognition Study, Institute of Molecular Biomembrane and Glycobiolgy, Tohoku Pharm
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