Circumvention of Acquired Resistance to Doxorubicin in K562 Human Leukemia Cells by Oxatomide
スポンサーリンク
概要
- 論文の詳細を見る
We studied the effect of oxatomide, an antiallergic drug, on the resistance of K562 cells to doxorubicin. oxatomide synergistically potentiated the cytotoxicity of doxorubicin in doxorubicin-resistant K562 cells(K562/DXR)at a concentration of 1-10μM, but had hardly any synergistic effect on the parental cell line(K562)at the same concentration Oxatomide inhibit P-glycoprotein pump-efflux activity and the binding of [^3H]-azi-dopine to the cell-surface protein P-glycoprotein, in a dose-related manner. These results indicate that oxatomide reverses the multidrug-resistance phenotype through direct interaction with P-glycoprotein.
- 社団法人日本薬学会の論文
- 2001-10-01
著者
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SATOH Susumu
Department of Pharmacology and Pharmacotherapy, Nihon Pharmaceutical University
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ISHIKAWA Masaaki
Department of Pharmacology and Toxicology, Cancer Research Institute, Tohoku Pharmaceutical Universi
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TAKAYANAGI Motoaki
Department of Pathophysiology, Tohoku Pharmaceutical University
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Sasaki K
Dep. Of Pharmacology And Toxicology Cancer Res. Inst. Tohoku Pharmaceutical Univ.
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Takayanagi M
Department Of Pathophysiology Tohoku Pharmaceutical University
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Takayanagi Motoaki
Department Of Pharmacology And Toxicology Cancer Research Institute Tohoku Pharmaceutical University
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Takayanagi Motoaki
Cancer Research Institute Tohoku Pharmaceutical University
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FUJITA Ryousuke
Department of pharmacology and Toxicology, Cancer Research Institute, Tohoku Pharmaceutical Universi
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FURUSAWA Shinobu
Department of pharmacology and Toxicology, Cancer Research Institute, Tohoku Pharmaceutical Universi
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SASAKI Ken-ichi
Department of pharmacology and Toxicology, Cancer Research Institute, Tohoku Pharmaceutical Universi
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FURUSAWA Shinobu
Cancer Research Institute, Tohoku Pharmaceutical University
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Ishikawa Masaaki
東北薬科大学癌研究所
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Ishikawa Masaaki
Department Of Clinical Pharmacotherapeutics Tohoku Pharmaceutical University
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Ishikawa Masaaki
Department Of Pharmacology And Toxicology Cancer Research Institute Tohoku Pharmaceutical University
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Ishikawa Masaaki
Department Of Pharmacology And Toxicology Cancer Research Institute Tohoku College Of Pharmacy
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Kanno Shu-ichi
Department Of Pharmacology And Toxicology Cancer Research Institute Tohoku Pharmaceutical University
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SASAKI Kenichi
Cancer Research Institute, Tohoku College of Pharmacy
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Satoh Susumu
Department Of Pharmacology And Toxicology Cancer Research Institute Tohoku Pharmaceutical University
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Satoh Susumu
Department Of Neurosurgery Yamagata Prefectural Central Hospital
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Sasaki Ken-ichi
Department Of Pharmacology And Toxicology Cancer Research Institute Tohoku Pharmaceutical University
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Sasaki Ken-ichi
Department Of Pathology Sapporo Medical University School Of Medicine
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Fujita Ryousuke
Department Of Pharmacology And Toxicology Cancer Research Institute Tohoku Pharmaceutical University
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Sasaki Ken-ichi
Department Of Chemistry Faculty Of Science Hiroshima University
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