Effect of forskolin on prostaglandin productions in isolated dog renal arteries.
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概要
- 論文の詳細を見る
Forskolin (1 to 100 μM), a direct activator of adenylate cyclase, did not have any effect on prostaglandin E<SUB>2</SUB> and I<SUB>2</SUB> productions in isolated dog renal arteries. However, forskolin at the lower concentrations (10 and 100 nM) markedly stimulated only prostaglandin E<SUB>2</SUB> production. 8-Bromo-cyclic AMP (0.5 and 1 mM) failed to stimulate prostaglandin E<SUB>2</SUB> and I<SUB>2</SUB> productions. The results suggest that 1) forskolin stimulates only prostaglandin E<SUB>2</SUB> production, not through the activation of adenylate cyclase and 2) the prostaglandin production system may be independent of the cyclic AMP-generating system in isolated dog renal arteries.
- 公益社団法人 日本薬理学会の論文
著者
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Kurosawa Hideo
Department Of Applied Chemistry Faculty Of Engineering Osaka University
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Satoh Susumu
Department Of Neurosurgery Yamagata Prefectural Central Hospital
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Satoh Hiroyuki
Department Of Biology Faculty Of Science Toho University
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SUZUKI Junko
Department of Advanced Energy, University of Tokyo
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KUROSAWA Hideo
Department of Pharmacology, Pharmaceutical Institute, Tohoku University
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YATSU Takeyuki
Department of Pharmacology, Pharmaceutical Institute, Tohoku University
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SATOH Hiroyuki
Department of Pharmacology, Pharmaceutical Institute, Tohoku University
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