Inhibitory Effect of Trimidox on Lipopolysaccharide-Induced Nitric Oxide Production in RAW 264.7 Macrophages
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概要
- 論文の詳細を見る
We examined the effect of trimidox (3,4,5-trihydroxybenzamidoxime) on the production of nitric oxide (NO) by lipopolysaccharide (LPS) in mouse RAW 264.7 macrophages. Trimidox (50 – 300 μM) concentration-dependently inhibited NO production by LPS (0.01, 0.1, or 1 μg/ml) after incubation for 24 h. LPS-induced expression of inducible NO synthase (iNOS) and degradation of IκBα were prevented by trimidox. The protective effect against NO production by LPS was not only observed in prior incubation but also later incubation with trimidox until iNOS was activated by LPS. These results suggest that trimidox has a predominantly protective effect against LPS-induced production of NO via iNOS expression.
- 社団法人 日本薬理学会の論文
- 2007-07-20
著者
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ISHIKAWA Masaaki
Department of Pharmacology and Toxicology, Cancer Research Institute, Tohoku Pharmaceutical Universi
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KANNO Syu-ichi
Department of Clinical Pharmacotherapeutics, Tohoku Pharmaceutical University
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KITAJIMA Yasue
Department of Clinical Pharmacotherapeutics, Tohoku Pharmaceutical University
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KAKUTA Mai
Department of Clinical Pharmacotherapeutics, Tohoku Pharmaceutical University
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OSANAI Yuu
Department of Clinical Pharmacotherapeutics, Tohoku Pharmaceutical University
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KURAUCHI Kaori
Department of Clinical Pharmacotherapeutics, Tohoku Pharmaceutical University
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UJIBE Mayuko
Department of Clinical Pharmacotherapeutics, Tohoku Pharmaceutical University
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Kakuta Mai
Department Of Clinical Pharmacotherapeutics Tohoku Pharmaceutical University
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Osanai Yuu
Department Of Clinical Pharmacotherapeutics Tohoku Pharmaceutical University
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Ujibe Mayuko
Department Of Clinical Pharmacotherapeutics Tohoku Pharmaceutical University
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Kanno Syu-ichi
Department Of Clinical Pharmacotherapeutics Tohoku Pharmaceutical University
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Kanno Syu-ichi
東北薬科大学癌研究所
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Kimura Katsuhiko
Department Of Clinical Pharmacotherapeutics Tohoku Pharmaceutical University
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Kitajima Yasue
Department Of Clinical Pharmacotherapeutics Tohoku Pharmaceutical University
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Kanno Syu-ichi
東北薬科大学 薬物治療学教室
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OHTAKE Takaharu
Department of Clinical Pharmacotherapeutics, Tohoku Pharmaceutical University
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TAKESHITA Mituhiro
Department of Pharmaceutics, Tohoku Pharmaceutical University
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Kanno Syu-ichi
Department Of Pharmacology And Toxicology Cancer Research Institute Tohoku Pharmaceutical University
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UWAI Kouji
Department of Pharmaceutics, Tohoku Pharmaceutical University
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Ishikawa Masaaki
Department Of Clinical Pharmacotherapeutics Tohoku Pharmaceutical University
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Ishikawa Masaaki
Department Of Pharmacology And Toxicology Cancer Research Institute Tohoku Pharmaceutical University
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Ishikawa Masaaki
Department Of Pharmacology And Toxicology Cancer Research Institute Tohoku College Of Pharmacy
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Uwai Kohji
Department Of Pharmacology Tohoku Pharmaceutical University
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Koiwai Kimiko
Department Of Pharmacology And Toxicology Cancer Research Institute Tohoku Pharmaceutical University
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Ohtake Takaharu
Department Of Clinical Pharmacotherapeutics Tohoku Pharmaceutical University
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Ishikawa Masaaki
Dep. Of Clinical Pharmacotheraputics Tohoku Pharmaceutical Univ. Jpn
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Takeshita Mitsuhiro
Department Of Pharmacology Tohoku Pharmaceutical University
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