Inhibitory Effects of Naringenin on Tumor Growth in Human Cancer Cell Lines and Sarcoma S-180-Implanted Mice(Pharmacology)

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概要

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• We have investigated the effect of naringenin (NGEN) on tumor growth in various human cancer cell lines and sarcoma S-180-implanted mice. NGEN showed cytotoxicity in cell lines derived from cancer of the breast (MCF-7, MDA-MB-231), stomach (KATOIII, MKN-7), liver (HepG2, Hep3B, Huh7), cervix (Hela, Hela-TG), pancreas (PK-1), and colon (Caco-2) as well as leukemia (HL-60, NALM-6, Jurkat, U937). NGEN-induced cytotoxicity was low in Caco-2 and high in leukemia cells compared to other cell lines. NGEN dose-dependently induced apoptosis, with hypodiploid cells detected in both Caco-2 and HL-60 by flow cytometric analysis. In vivo, NGEN inhibited tumor growth in sarcoma S-180-implanted mice, following intraperitoneal or peroral injection once a day for 5d. Naringin (NG) also inhibited tumor growth by peroral injection but not intraperitoneal injection. NGEN, one of the most abundant flavonoids in citrus fruits, may have a potentially useful inhibitory effect on tumor growth.

• 公益社団法人日本薬学会の論文
• 2005-03-01

著者

• ISHIKAWA Masaaki

  Department of Pharmacology and Toxicology, Cancer Research Institute, Tohoku Pharmaceutical Universi

• OSANAI Yuu

  Department of Clinical Pharmacotherapeutics, Tohoku Pharmaceutical University

• UJIBE Mayuko

  Department of Clinical Pharmacotherapeutics, Tohoku Pharmaceutical University

• Osanai Yuu

  Department Of Clinical Pharmacotherapeutics Tohoku Pharmaceutical University

• Ujibe Mayuko

  Department Of Clinical Pharmacotherapeutics Tohoku Pharmaceutical University

• Kanno Syu-ichi

  Department Of Clinical Pharmacotherapeutics Tohoku Pharmaceutical University

• Kanno Syu-ichi

  東北薬科大学癌研究所

• Kimura Katsuhiko

  Department Of Clinical Pharmacotherapeutics Tohoku Pharmaceutical University

• Kanno Syu-ichi

  東北薬科大学 薬物治療学教室

• OHTAKE Takaharu

  Department of Clinical Pharmacotherapeutics, Tohoku Pharmaceutical University

• Kanno Syu-ichi

  Department Of Pharmacology And Toxicology Cancer Research Institute Tohoku Pharmaceutical University

• TOMIZAWA Ayako

  Department of Pharmacology and Toxicology, Cancer Research Institute, Tohoku Pharmaceutical Universi

• HIURA Takako

  Department of Pharmacology and Toxicology, Cancer Research Institute, Tohoku Pharmaceutical Universi

• SHOUJI Ai

  Department of Clinical Pharmacotherapeutics, Tohoku Pharmaceutical University

• KANNO Syuichi

  Department of Pharmacology and Toxicology, Cancer Research Institute, Tohoku Pharmaceutical Universi

• KIMURA Katsuhiko

  Tohoku Employees' Pension Welfare Hospital

• Ishikawa Masaaki

  Department Of Clinical Pharmacotherapeutics Tohoku Pharmaceutical University

• Ishikawa Masaaki

  Department Of Pharmacology And Toxicology Cancer Research Institute Tohoku Pharmaceutical University

• Ishikawa Masaaki

  Department Of Pharmacology And Toxicology Cancer Research Institute Tohoku College Of Pharmacy

• Kanno Syuichi

  Department Of Clinical Pharmacotherapeutics Tohoku Pharmaceutical University

• Shouji Ai

  Department Of Clinical Pharmacotherapeutics Tohoku Pharmaceutical University

• Hiura Takako

  Department Of Clinical Pharmacotherapeutics Tohoku Pharmaceutical University

• Koiwai Kimiko

  Department Of Pharmacology And Toxicology Cancer Research Institute Tohoku Pharmaceutical University

• Tomizawa Ayako

  Department Of Pharmacology And Toxicology Cancer Research Institute Tohoku Pharmaceutical University

• Ohtake Takaharu

  Department Of Clinical Pharmacotherapeutics Tohoku Pharmaceutical University

• Ishikawa Masaaki

  Dep. Of Clinical Pharmacotheraputics Tohoku Pharmaceutical Univ. Jpn

• Kimura Katsuhiko

  Tohoku College Of Pharmacy

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