DETERMINATION OF AROMATASE ACTIVITY INVOLVED IN THE FORMATION OF ESTRIOL WITH HUMAN PLACENTAL MICROSOMES AND ITS KINETIC PROPERTIES

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概要

• 論文の詳細を見る
• 公益社団法人日本薬学会の論文

著者

• 沼沢 光輝

  Tohoku Pharmaceutical University

• NUMAZAWA Mitsuteru

  Tohoku College of Pharmacy

• Nagaoka M

  Tohoku Pharmaceutical Univ. Sendai Jpn

• Nagaoka Masao

  Tohoku College Of Pharmacy:sankyo Co. Ltd.

• Nagaoka Masao

  Tohoku College Of Pharmacy

• KIMURA Katsuhiko

  Tohoku Employees' Pension Welfare Hospital

• OSAWA YOSHIO

  Medical Foundation of Buffalo, Inc.

• Osawa Yoshio

  Hauptman-woodward Medical Research Institute Inc.

• OGATA MIEKO

  Tohoku College of Pharmacy

• Kimura Katsuhiko

  Tohoku College Of Pharmacy

関連論文

• アロマターゼの自殺基質ATとシステインとの反応性
• Synthesis and GC-MS of 6-Alkylestradiols, Possible Aromatase Reaction Products of 6-Alkylandrostenediones
• Kinetic Analysis of Reversible Inhibition of 16α-Hydroxyandrostenedione Aromatization in Human Placental Microsomes by Suicide Substrates of Androstenedione Aromatization
• Gas Chromatography-Mass Spectrometric Determination of Activity of Human Placental Aromatase Using 16α-Hydroxyandrostenedione as a Substrate
• Synthesis of 19-Oxygenated 4β, 5β-Epoxy Derivatives of 16α-Hydroxyandrostenedione as Mechanistic and Catalytic Probes for Aromatase Reaction
• C(10)-C(19) Bond Cleavage Reaction of 19-Oxygenated Androst-4-ene-3,6-dione Steroids under Various Conditions
• Improved Synthesis and Molecular Modeling of 4β,19-Dihydroxyandrost-5-en-17-one, an Excellent Inhibitor of Aromatase
• Androst-4-ene-17-thione とその 5-ene 異性体の合成とアロマターゼ阻害活性
• Aromatization of 19-Oxygenated Androst-4-ene-3,6,17-triones with Human Placental Microsomes
• Biochemical Studies of Estr-4-ene-3,6,17-trione and 5α-Androstan-17-ones with or without a Carbonyl Function at C-3 and/or C-6 as Aromatase Inhibitors
• キャピラリーFTD-GCによる玄米および大豆中15種有機含窒素系農薬の一斉分析法
• アロマターゼ自殺基質Androst-4-ene-3,6,17-trioneの19位酸素化体とN-Acetyl-_L-cysteineとの1,4-付加反応
• Synthesis of Deuterium-Labeled 16α, 19-Dihydroxy C_ Steroids as Internal Standards for Gas Chromatography-Mass Spectrometry
• A Radiometric Assay Method for Aromatase Activity Using [1β-^3H]16α-Hydroxyandrostenedione
• Competitive Inhibition and Suicide Inactivation of Human Placental Aromatase by Androst-4-ene-3,6-dione Derivatives and 3α-Methoxyandrost-4-ene-6,17-dione
• Synthesis of 16α-Hydroxyandrost-4-ene-3,17,19-trione and 3β, 16α-Dihydroxyandrost-5-ene-17,19-dione : Potential Intermediates of Estriol Biosynthesis
• Oxygenation of 2,4-Dibromoestrogens with Nitric Acid : A New Synthesis of 19-Nor Steroids
• Radioimmunoassay of 2-Hydroxyestrone Using Antisera Raised against Antigenic Complexs Obtained by Convenient Methods
• Time-Dependent Inactivation of Human Placental Aromatase by Bromoacetoxy 4-Androsten-3-ones in the Presence of Reduced Nicotinamide Adenine Dinucleotide Phosphate (NADPH)
• Reactions of Enolizable Steroidal 4-En-3-ones and 17-Ones with Hypervalent Iodine
• Stereospecific 1,2-Hydride Shift in the Rearrangement of 16β-Hydroxy-17-oxo Steroids to 17β-Hydroxy-16-ones with Acid and Base(Organic,Chemical)
• Preparation of [1,2-^3H,4-^C]16α-Hydroxyandrostenedione and Its Use for Radiometric Determination of Human Placental Aromatase Activity(Analytical,Chemical)
• Regiospecific Deoxygenation of the Dihydroxyacetone Moiety at C-17 of Corticoid Steroids with Iodotrimethylsilane
• Reaction of 21-Bromo-17α-methoxy-20-ketopregnenes with Sodium Methoxide or Potassium Acetate
• Synthesis and Biochemical Studies of 19-Oxygenated Derivatives of 6α- and 6β-Methylandrostenediones as Catalytic Probes for the Active Site of Aromatase
• Inhibitory Effects of Naringenin on Tumor Growth in Human Cancer Cell Lines and Sarcoma S-180-Implanted Mice(Pharmacology)
• IMMUNOCYTOCHEMICAL STUDY ON THE LOCALIZATION OF AROMATASE IN THE OVARY OF GOLDEN HAMSTER, GUINEA PIG AND COW
• IMMUNOCYTOCHEMICAL LOCALIZATION OF AROMATASE IN OVARIES OF SOME RODENTS, COW AND HUMAN
• Synthesis of Deuterium-Labelled 16α-Hydroxy-4-androstene-3,17-dione and 16α-Hydroxydehydroepiandrosterone
• Synthesis of Deuterium-labelled Estriol, 16α-Hydroxyestrone and Estriol 16-Glucuronide via 2,4,16α-Tribromoestrone as Internal Standards for Mass Fragmentography
• 急性心筋梗塞のマ-カ-酵素としてのクレアチンキナ-ゼ
• Purification and Characterization of Sialidase from Porcine Liver
• 19-Oxygenation of C_-Steroids with an A, B-Ring Enone Structure, Competitive Inhibitors of Estrogen Biosynthesis, with Human Placental Aromatase
• Effects of Inorganic Anions on the Activation of Acid Sialidases
• Effect of Sulfated Compounds on Acid Sialidase
• Aromatase Inhibition by 4β, 5β-Epoxides of 16α-Hydroxyandrostenedione and Its 19-Oxygenated Analogs, Potential Precursors of Estriol Production in the Feto-Placental Unit
• Identification of 16α, 19-Dihydroxyandrostenedione in the Serum of Pregnant Women by Gas Chromatography-Mass Spectrometry
• Synthesis of Deuterium-Labeled Androst-5-ene-17β, 19-diol and Its 4-Ene Isomer as Internal Standards for the Determination of the 19-Oxygenation of Aromatase Inhibitors Using GC-MS
• Stereochemistry of NaBH_4 Reduction of a 19-Carbonyl Group of 3-Deoxy Androgens. Synthesis of [19S-^3H]- and [19R-^3H]-Labeled Aromatase Inhibitors Having a 19-Hydroxy Group
• DETERMINATION OF AROMATASE ACTIVITY INVOLVED IN THE FORMATION OF ESTRIOL WITH HUMAN PLACENTAL MICROSOMES AND ITS KINETIC PROPERTIES
• Formation of 17β-Alkoxy-16-keto Steroids by Reaction of 16α-Hydroxy-17-keto and 17β-Hydroxy-16-keto Steroids with Trimethylsilyl Iodide in the Presence of Alkyl Alcohols
• Structure-Activity Relationships of Estrogen Derivatives as Aromatase Inhibitors. Effects of Heterocyclic Substituents
• Mechanistic Studies of Deoxygenation of Steroidal Ring-D 16,17-Ketols with trimethylsilyl Iodide
• Deoxygenation of Steroidal Ring-D 16,17-Ketols with Trimethylsilyl Iodide
• Aromatase Inactivation by a Suicide Substrate, Androst-5-ene-4,7,17-trione : The 5β, 6β-Epoxy-19-oxo Derivative, as a Possible Reactive Electrophile Irreversibly Binding to the Active Site
• 19-Oxygenated Derivatives of Androst-4-ene-6,17-dione and Androst-5-ene-4,17-dione as Catalytic Probes for the Active Site of Aromatase
• Gas Chromatography-Mass Spectrometric Study of 19-Oxygenation of the Aromatase Inhibitor 19-Methylandrostenedione with Human Placental Microsomes(Analytical Biochemistry)
• Reduction of 1,4-Dien-3-one Steroids with LiAl^2H_4 or NaB^2H_4 : Stereospecific Deuterium-Labeling at the C-1α Position of a 4-En-3-one Steroid
• Studies of the Time-Dependent Inactivation of Aromatase by 4β, 5β-Epoxy-6-one and 5β, 6β-Epoxy-4-one Steroids under Various Conditions
• Synthesis and Biochemical Properties of 6-Bromoandrostenedione Derivatives with a 2,2-Dimethyl or 2-Methyl Group as Aromatase Inhibitors(Medicinal Chemistry)

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