Regiospecific Deoxygenation of the Dihydroxyacetone Moiety at C-17 of Corticoid Steroids with Iodotrimethylsilane
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概要
- 論文の詳細を見る
Reaction of the corticoids 1-6 with iodotrimethylsilane in MeCN produced the regiospecifically deoxygenated products, 21-hydroxy-20-ketones 7-11,in moderate to high yields. On the other hand, employment of CHCl_3 as a solvent resulted in lower yields of the 21-ketols 7 and 8,accompanied by increased production of the 20-ketones 12 and 13. The 21-ketol 7 was efficiently converted into the 20-ketone 12,while the 17α-hydroxy isomer 14 was recovered unchanged. Rapid and quantitative conversion of the 21-iodo-20-ketone 17 into the 20-ketone 12 by this iodosilane treatment suggests that the conversion of the ketol 7 into the ketone 12 probably occurs via the iodide 17.
- 公益社団法人日本薬学会の論文
- 1986-09-25
著者
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沼沢 光輝
Tohoku Pharmaceutical University
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沼沢 光輝
Tohoku College Of Pharmacy
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長岡 正男
東北薬科大学
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長岡 正男
Tohoku College of Pharmacy
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国玉 ユリエ
Tohoku College of Pharmacy
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