ピペリジンN-誘導体のマウスおよびラット肝酵素系によるN-C開裂について

概要

論文の詳細を見る
Examinations were made on the N-C cleavage of nitrogen-derivatives of piperidine by the 9000×g supernatant of mouse and rat liver in vitro. The derivatives examined were N-methylpiperidine (I), N-ethylpiperidine (II), N-(2-hydroxyethyl) piperidine (III), N-carboxymethylpiperidine (IV), N-cinnamylpiperidine (V), and three kinds of Mannich base of piperidine. Results obtained may be summarized as follows : 1) The rat liver supernatant showed greater cleavage activity than the mouse liver supernatant for all the derivatives examined. The order of N-C cleavage of these derivatives was approximately the same with the liver of both animals. 2) Cleavage of the N-ethyl derivatives (I, II, III, and IV) was small with both mouse and rat liver supernatants, and that of the Mannich bases was greater. V showed cleavage of a degree intermediate of these two. 3) Phenobarbital induced cleavage activity of both mouse and rat liver supernatant, while 3-methylcholanthrene had no effect on the cleavage with the exception of the Mannich bases in which it showed a slight induction. 4) Inhibition of cleavage activity to a considerable degree was seen by pretreatment of mice and rats with SKF-525A.
公益社団法人日本薬学会の論文
1979-03-25