Effect of Sulfated Compounds on Acid Sialidase

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概要

• 論文の詳細を見る

• The inhibitory effects of various sulfated compounds on the activitives of sialidases purified from porcine liver and human placenta were investigated. Among the sulfated compounds tested, heparin, dextran sulfate, condroitin sulfates and sulfatide significantly inhibited the 4-methylumbelliferyl-α-N-acetylneuraminic acid (4-MU-NeuAc) sialidase activities of the two enzyme preparations, but glucose 6-sulfate and glucosamine 6-surfate did not. Potassium sulfate showed an inhibitory effect only at high concentrations. When the sialidase activities were measured using natural substrates, the sialidase activities for the (α2-3) and (α2-6) sialyllactoses, and colominic acid, were markedly inhibited by heparin and sulfatide similar to 4-MU-NeuAc, although the fetuin sialidase activity was not significantly influenced by them. The sialidase activity hydrolyzing GM3 was strongly inhibited by heparin, but not by sulfatide.

• 公益社団法人日本薬学会の論文
• 1998-11-15

著者

• 沼沢 光輝

  Tohoku Pharmaceutical University

• Shiraishi Takayuki

  Department of Health Chemistry , Niigata College of Pharmacy

• Nagaoka M

  Tohoku Pharmaceutical Univ. Sendai Jpn

• Nagaoka Masao

  Tohoku College Of Pharmacy:sankyo Co. Ltd.

• UDA Yutaka

  Department of Health Chemistry, Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy a

• FURUHATA Kimio

  Scohool of Pharmaceutical Sciences, Kitasato University

• Shiraishi Takayuki

  Laboratoiy Of Health Chemistry Faculty Of Pharmaceutical Science Niigata University Of Pharmacy And

• Uda Y

  Department Of Health Chemistry Faculty Of Pharmaceutical Sciences Niigata University Of Pharmacy And

• Uda Yutaka

  Department Of Chemical Toxicology Medical Research Institute Tokyo Medical And Dental University

• Furuhata K

  Scohool Of Pharmaceutical Sciences Kitasato University

• Furuhata Kimio

  School Of Pharmaceutical Sciences Kitasato University

• NAGAOKA Megumi

  Department of Health Chemistry, Niigata College of Pharmacy

• FURUHATA Kimio

  Department of Pharmaceutical Chemistry, School of Pharmaceutical Science, Kitazato University

• 白石 達郎

  Hoechst Japan Co. Ltd.

• Shiraishi Takayuki

  Department of Electrical and Computer Engineering, Graduate School of Engineering, Yokohama National University, Yokohama 240-8501, Japan

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