Purification and Characterization of α-N-Acetylgalactosaminidases I and II from the Starfish Asterina amurensis

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概要

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• Two α-N-acetylgalactosaminidases, α-N-acetylgalactosaminidase (α-GalNAcase) I and II, were purified from the digestive organ of starfish. Purified α-GalNAcase I and II gave nearly single protein bands on SDS-polyacrylamide gel electrophoresis, individually. Even the final preparation of α-GalNAcase I contained α-galactosidase activity, while α-GalNAcase II was almost free from that activity with p-nitrophenyl and 4-methylumbelliferyl α-N-acetylgalactosaminides as substrates. α-GalNAcase I and II both hydrolyzed terminal α-N-acetylgalactosaminyl linkages of the natural compounds investigated: Forssman hapten glycolipid, blood group A active oligosaccharide and GalNAc-α1-O-serine. On the other hand, oligosaccharides, and glycolipid containing α-galactosyl terminals were hydrolyzed by α-GalNAcase I but not by α-GalNAcase II. The substrate specificities and other enzymatic properties of α-GalNAcase I were similar to those of human placental α-GalNAcase, but distinct from α-GalNAcase II.

• 社団法人 日本農芸化学会の論文
• 2010-02-23

著者

• Ando Masayuki

  Department Of Health Chemistry Faculty Of Pharmaceutical Sciences Niigata University Of Pharmacy And

• Harun-or-rashid Md.

  Department Of Biochemistry Bangladesh Agricultural University

• SATOH YOUICHI

  Department of Cardiovascular Surgery, Faculty of Medicine, Fukushima Medical University

• Shiraishi Takayuki

  Laboratoiy Of Health Chemistry Faculty Of Pharmaceutical Science Niigata University Of Pharmacy And

• Ando Masayuki

  Department Of Biotechnology Graduate School Of Engineering Osaka University

• Uda Y

  Department Of Health Chemistry Faculty Of Pharmaceutical Sciences Niigata University Of Pharmacy And

• Uda Yutaka

  Department Of Chemical Toxicology Medical Research Institute Tokyo Medical And Dental University

• Satoh Youichi

  Department Of Health Chemistry Faculty Of Pharmaceutical Sciences Niigata University Of Pharmacy And

• Harun-or-rashid Md.

  Department Of Health Chemistry Faculty Of Pharmaceutical Sciences Niigata University Of Pharmacy And

• Shiraishi Takayuki

  Laboratory Of Health Chemistry Nihon Pharmaceutical University

• Sadik Golam

  Department Of Health Chemistry Faculty Of Pharmaceutical Sciences Niigata University Of Pharmacy And

• MATSUZAWA Tomomi

  Department of Health Chemistry, Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy a

• Matsuzawa Tomomi

  Department Of Health Chemistry Faculty Of Pharmaceutical Sciences Niigata University Of Pharmacy And

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