The Presence of Ceramidase Activity in Liver Nuclear Membrane

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概要

• 論文の詳細を見る

• This report presents a demonstration of ceramidase activity in the nuclear membrane or envelope of mammalian livers. The products of ceramidase reaction were identified by means of TLC for released fatty acid and HPLC for sphingosine. The ceramidase activity was maximum over a broad neutral to alkaline region ranging from pH 7.0 to 8.8. This activity was inhibited by N-oleoylethanolamine known as a specific inhibitor for ceramidase and by anandamide to a similar extent. The enzymatic study suggests that the nuclear ceramidase has different properties from other ceramidase reported previously. As sphingomyelinase, one of enzymes involved in the sphingomyelin cycle, are known to be present in the nuclear membrane, it is now evident that at least two enzymes involved in the sphingomyelin cycle are present in the nuclear membrane.

• 公益社団法人日本薬学会の論文
• 2003-06-01

著者

• Shiraishi Takayuki

  Department of Health Chemistry , Niigata College of Pharmacy

• UDA Yutaka

  Department of Health Chemistry, Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy a

• Uda Yutaka

  Department Of Chemical Toxicology Medical Research Institute Tokyo Medical And Dental University

• Uda Yutaka

  Department Of Health Chemistry Faculty Of Pharmaceutical Science Niigata University Of Pharmacy And

• IMAI Shinichiro

  Department of Health Chemistry, Faculty of Pharmaceutical Science, Niigata University of Pharmacy an

• Imai Shinichiro

  Department Of Health Chemistry Faculty Of Pharmaceutical Science Niigata University Of Pharmacy And

• Shiraishi Takayuki

  Department Of Health Chemistry Faculty Of Pharmaceutical Science Niigata University Of Pharmacy And

• Shiraishi Takayuki

  Department of Electrical and Computer Engineering, Graduate School of Engineering, Yokohama National University, Yokohama 240-8501, Japan

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