Identification of 16α, 19-Dihydroxyandrostenedione in the Serum of Pregnant Women by Gas Chromatography-Mass Spectrometry

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概要

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• 16α, 19-Dihydroxyandrostenedione[16α, 19-(OH)_2AD], a potential precursor of estriol, was identified in the serum of pregnant women by gas chromatography-mass spectrometry(GC-MS). Preliminary study indicated that the average serum concentration of 16α, 19-(OH)_2AD in 10 normal pregnant women was 154.2±20pg/ml. In contrast, the serum concentration of 16α, 19-dihydroxydehydroepiandrosterone was less than the detection limit(30pg/ml)of the GC-MS method.

• 公益社団法人日本薬学会の論文
• 2001-08-01

著者

• 沼沢 光輝

  Tohoku Pharmaceutical University

• NUMAZAWA Mitsuteru

  Tohoku College of Pharmacy

• NAGAOKA Masao

  Tohoku Pharmaceutical University

• Nagaoka M

  Tohoku Pharmaceutical Univ. Sendai Jpn

• Nagaoka Masao

  Tohoku College Of Pharmacy:sankyo Co. Ltd.

• Nagaoka Masao

  Tohoku College Of Pharmacy

• HONJO Hideo

  Department of Obstetrics and Gynecology

• Honjo H

  Department Of Obstetrics And Gynecology Kyoto Prefectural University Of Medicine

• Osawa Yoshio

  Hauptman-woodward Medical Research Institute Inc.

• Satoh S

  Tohoku Pharmaceutical University

• SATOH Satoshi

  Tohoku Pharmaceutical University

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