Deoxygenation of Steroidal Ring-D 16,17-Ketols with Trimethylsilyl Iodide
スポンサーリンク
概要
- 論文の詳細を見る
Reaction of various steroidal 16,17-ketols, 16α-hydroxy-17-ketones 1-3,and 15,16β-hydroxy-17-ketone 4,and 17β-hydroxy-16-ketones 5-7,and 17,along with methyl ethers of 16α- and 17β-ketols, 1 and 5,with an excess of trimethylsilyl iodide (TMSI) or with HI in CHCl_3,produced the deoxygenated products, a mixture of the corresponding 17-and 16-ketones, in low to quantitative yields, in which the 17-ketone was the major product in each case. When the 16β-deuterated 16α-ketol 3 and the 17α-deuterated 17β-ketol 7 were reached with TMSI for a brief period (15 min), the deuterium content at C-16β and C-17α of the recovered steroids 3 and 7 was reduced by 17 and 35%, respectively. The present results indicate that the deoxygenation proceeds not only through a direct iodination pathway producing α-iodoketone but also through other reaction pathways.
- 公益社団法人日本薬学会の論文
- 1998-12-15
著者
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沼沢 光輝
Tohoku Pharmaceutical University
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NUMAZAWA Mitsuteru
Tohoku College of Pharmacy
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Nagaoka M
Tohoku Pharmaceutical Univ. Sendai Jpn
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Nagaoka Masao
Tohoku College Of Pharmacy:sankyo Co. Ltd.
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Nagaoka Masao
Tohoku College Of Pharmacy
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NAGASAWA Etsuko
Tohoku College of Pharmacy
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Nagasawa Etsuko
Tohoku College Of Pharmacy:sankyo Co. Ltd.
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