Reduction of 1,4-Dien-3-one Steroids with LiAl^2H_4 or NaB^2H_4 : Stereospecific Deuterium-Labeling at the C-1α Position of a 4-En-3-one Steroid
スポンサーリンク
概要
- 論文の詳細を見る
Reduction of a double bond at C-1 of 1, 4-dien-3-one steroids 7 and 8 with LiAl^2H_4 in THF or NaB^2H_4 in MeOH and H_2O gave stereospecifically [1α-^2H]-labeled 4-en-3-one steroids 9 and 10, respectively. When the deuterated solvents, MeO^2H and ^2H_2O, were used for the reaction of steroid 8 with NaB^2H_4, [1α, 2ξ-^2H_2]-labeled compound 10 was produced. This indicates that the reaction proceeds through the initial hydride attack at the C-1 α position, followed by ketonization of the 2-en-3-ol intermediate.
- 公益社団法人日本薬学会の論文
- 2006-04-01
著者
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NUMAZAWA Mitsuteru
Tohoku College of Pharmacy
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Numazawa Mitsuteru
Tohoku Pharmaceutical University
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HANDA Wakako
Tohoku Pharmaceutical University
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