C(10)-C(19) Bond Cleavage Reaction of 19-Oxygenated Androst-4-ene-3,6-dione Steroids under Various Conditions
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概要
- 論文の詳細を見る
C(10)-C(19) bond cleavage reaction of 19-hydroxy- and 19-oxoandrost-4-ene-3,6,17-triones (5, 6) was explored under various conditions. Treatment of steroids 5 and 6 with KOH in MeOH gave the A-ring aromatized product 6-oxoestrone (11) in a fair yield, respectively, in contrast, the treatment with a weak base yielded 4-methyl steroid 17 (20%) in the case of 19-alcohol 5 or 19-nor-Δ^<5(10)>-steroid 9 (12-67%) along with compound 11 (6-27%) in the case of 19-aldehyde 6. Reaction of compound 6 with HCl in MeOH produced 3-methyl ethers of 6-oxoestrone and Δ^6-estrone, compounds 12 and 14 (ca. 20% each). Thus, 6-oxosteroids 5 and 6 showed unique C(10)-C(19) bond cleavage reactions with a base or acid.
- 公益社団法人日本薬学会の論文
- 2004-08-01
著者
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沼沢 光輝
Tohoku Pharmaceutical University
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NUMAZAWA Mitsuteru
Tohoku College of Pharmacy
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NAGAOKA Masao
Tohoku Pharmaceutical University
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Nagaoka M
Tohoku Pharmaceutical Univ. Sendai Jpn
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Nagaoka Masao
Tohoku College Of Pharmacy:sankyo Co. Ltd.
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Nagaoka Masao
Tohoku College Of Pharmacy
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