A Novel Glycosylation of 3-Deoxy-D-glycero-D-galacto-2-nonulosonic Acid (KDN) via in Situ Pyranose-Furanose Rearrangement

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概要

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• In studies on the glycosylation of 3-deoxy-D-glycero-D-galacto-2-nonulosonic acid (KDN) derivatives, O-glycosides of furanose-type KDN were synthesized from benzyl 4,5,7,8,9-penta-O-acetyl-2-bromo-2,3-dideoxy-D-glycero-D-galacto-2-nonulopyranosonate under Koenigs-Knorr reaction conditions. The furanoid structures of the KDN moiety were supported by with ^1H-NMR experiments, and the reaction was considered as a novel glycosylation with ring contraction, which proceeded via in situ pyranose-furanose rearrangement of the KDN moiety, and subsequent coupling with acceptors.

• 公益社団法人日本薬学会の論文
• 1997-05-15

著者

• Takayanagi H

  School Of Pharmaceutical Sciences Kitasato University

• Takayanagi H

  Kitasato Univ. Tokyo Jpn

• Takayanagi Hiroaki

  School Of Pharmaceutical Sciences Kitasato University

• FURUHATA KIMIO

  School of Pharmaceutical Sciences, Kitasato University

• Sun X‐l

  School Of Pharmaceutical Sciences Kitasato University

• Sun Xue-long

  School Of Pharmaceutical Sciences Kitasato University

• KAI Toshitsugu

  School of Pharmaceutical Sciences, Kitasato University

• SUN Xue

  School of Pharmaceutical Sciences, Kitasato University

• FUJITA Syuji

  School of Pharmaceutical Sciences, Kitasato University

• FURUHATA Kimio

  Scohool of Pharmaceutical Sciences, Kitasato University

• Fujita S

  Showa Pharmaceutical Univ. Tokyo Jpn

• Furuhata K

  Scohool Of Pharmaceutical Sciences Kitasato University

• Furuhata Kimio

  School Of Pharmaceutical Sciences Kitasato University

• Kai Toshitsugu

  School Of Pharmaceutical Sciences Kitasato University

• Sun Xue

  School Of Pharmaceutical Sciences Kitasato University

• Takayanagi H

  School Of Pharmacy Kitasato University

• Takayanagi Hiroaki

  School of Parmaceutical Sciences, Kitasato University

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