Conformational Analysis of Methyl 2,3,4-Tri-O-acetyl-6-deoxy-6-phenylsulfinyl-α-D-glucoside

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概要

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• Conformational analysis of methyl 2,3,4-tri-O-acetyl-6-deoxy-6-(R)-phenylsulfinyl-α-D-glucopyranoside (1), methyl 2,3,4-tri-O-acetyl-6-deoxy-6-(S)-phenylsulfinyl-α-D-glucopyranoside (2) and methyl 2,3,4-tri-O-acetyl-6-deoxy-6-phenylsulfonyl-α-D-glucopyranoside (3) in solution (CDCl_3) and the crystalline state was carried out using ^1H-NMR spectra and X-ray crystallographic data. The conformational preference of the C6-S bond in the above mentioned compounds was found to be GT (GT is short for gauche-trans), and as a 1 : 1 mixture of rotamers for the (S)-S-oxide (2) and sulfone (3) but not in the (R)-S-oxide (1) in the solid state.

• 公益社団法人日本薬学会の論文
• 1998-08-15

著者

• Takayanagi H

  School Of Pharmaceutical Sciences Kitasato University

• Takayanagi H

  Kitasato Univ. Tokyo Jpn

• Takayanagi Hiroaki

  School Of Pharmaceutical Sciences Kitasato University

• Takeda K

  Tokyo Univ. Sci. Tokyo Jpn

• Takeda K

  Center For Advanced Technology Ebara Research Co. Ltd.

• Sato Tomoko

  School Of Pharmaceutical Sciences Kitasato University

• OSA Yumiko

  School of Pharmaceutical Sciences, Kitasato University

• TAKEDA Kazuyoshi

  Ebara Research Co., Ltd.,

• TSUMURAYA Hiroshi

  School of Pharmaceutical Sciences, Kitasato University

• MIZUNO Yoshihisa

  School of Pharmaceutical Sciences, Kitasato University

• Osa Y

  Kitasato Univ. Tokyo Jpn

• Osa Yumiko

  School Of Pharmaceutical Sciences Kitasato University

• Takayanagi H

  School Of Pharmacy Kitasato University

• Mizuno Yoshihisa

  School Of Pharmaceutical Sciences Kitasato University

• Tsumuraya Hiroshi

  School Of Pharmaceutical Sciences Kitasato University

• Takeda Kazuyoshi

  Ebara Research Co. Ltd.

• TAKAYANAGI Hiroaki

  School of Pharmaceutical Sciences, Kitasato University

• Takayanagi Hiroaki

  School of Parmaceutical Sciences, Kitasato University

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