Synthesis of Linear Tripeptides for Right-Hand Segments of Complestatin
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概要
- 論文の詳細を見る
This paper concerns a synthetic study of the right-hand segment of complestatin, an inhibitor of gp120-CD4 receptor. The effective synthesis of four important precursors for the right-hand segment of complestatin is described. Two of them are the precursor tripeptides for macrolactamization to the right-hand segment of complestatin at the last step and the other two are the precursor tripeptides for ring-closing reaction using Suzuki and Stille coupling, respectively, to the right-hand segment of complestatin at the last step. These compounds and the synthetic procedure will serve for both the synthesis of the right-hand segment and total synthesis of complestatin in the near future. In addition, consideration of the smooth acidic isomerization of complestatin to chloropeptin was carried out by density functional theory (DFT) calculation.
- 公益社団法人日本薬学会の論文
- 2005-10-01
著者
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Takeda K
Tokyo Univ. Sci. Tokyo Jpn
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Takeda K
Center For Advanced Technology Ebara Research Co. Ltd.
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HARIGAYA Yoshihiro
School of Pharmaceutical Sciences, Kitasato University
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KAI Toshitsugu
School of Pharmaceutical Sciences, Kitasato University
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Yamada Y
School Of Pharmaceutical Sciences Kitasato University
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Arima Shiho
School Of Pharmaceutical Sciences Kitasato University
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Arima Shiho
Research Center For Biological Function The Kitasato Institute And Kitasato University
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Okada Chiharu
School Of Pharmaceutical Sciences Kitasato University
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Kai Toshitsugu
School Of Pharmaceutical Sciences Kitasato University
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TAKEDA Kazuyoshi
Center for Advanced Technology, EBARA Research Co., Ltd.
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Yamada(konda) Yaeko
School Of Pharmaceutical Sciences Kitasato University
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YAMADA Yaeko
School of Pharmaceutical Sciences, Kitasato University
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AKIBA Ai
School of Pharmaceutical Sciences, Kitasato University
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YOSHIDA Kiminari
School of Pharmaceutical Sciences, Kitasato University
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ITOU Fumihiro
School of Pharmaceutical Sciences, Kitasato University
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SATOU Toshiko
School of Pharmaceutical Sciences, Kitasato University
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Harigaya Yoshihiro
Kitasato Univ. Tokyo Jpn
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Akiba Ai
School Of Pharmaceutical Sciences Kitasato University
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Yamada Yaeko
School Of Pharmaceutical Sciences Kitasato University
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Itou Fumihiro
School Of Pharmaceutical Sciences Kitasato University
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Satou Toshiko
School Of Pharmaceutical Sciences Kitasato University
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Yoshida Kiminari
Kitasato Institute For Life Sciences And Graduate School Of Infection Control Sciences Kitasato Univ
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Takeda Kazuyoshi
Center For Advanced Technology Ebara Reseach Co. Ltd.
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