Application of Intramolecular 1,3-Dipolar Cyclic Addition of Azide and Olefin; Construction of (Pyrrolidine-2-ylidene) glycinate and Glycinamides
スポンサーリンク
概要
- 論文の詳細を見る
Oxopropyl E-(pyrrolidine-2-ylidene)glycinamide (5c) and allyl E-(pyrrolidine-2-ylidene)glycinate (5d) were effectively synthesized from 2,3,5-tri-O-benzyl-4-O-tert-butyldimethylsilyl(TBDMS)-D-arabinal (7) using intramolecular 1,3-dipolar cyclic reaction of azide and olefin as a key reaction. These results proved this cyclic reaction should be applicable for the synthesis of various (pyrrolidine-2-ylidene)glycinate and glycinamide. In addition, the development of a synthetic route for the precursor of an unsaturated cyclic dehydro amino acid involved in azinomycins (carzinophilin) using relating glycinate, methyl E-(pyrrolidine-2-ylidene)glycinate (5a) was described.
- 公益社団法人日本薬学会の論文
- 2005-05-01
著者
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HARIGAYA Yoshihiro
School of Pharmaceutical Sciences, Kitasato University
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TAKEDA Kazuyoshi
Center for Advanced Technology, EBARA Research Co., Ltd.
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Monma Souichi
School Of Pharmaceutical Sciences Kitasato University
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Harigaya Yoshihiro
Kitasato Univ. Tokyo Jpn
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Yamada Yaeko
School Of Pharmaceutical Sciences Kitasato University
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ASANO Keiko
School of Pharmaceutical Sciences, Kitasato University
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SATOU Takahiro
School of Pharmaceutical Sciences, Kitasato University
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SAKAYANAGI Masataka
School of Pharmaceutical Sciences, Kitasato University
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SATOU Noriko
School of Pharmaceutical Sciences, Kitasato University
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Asano Keiko
School Of Pharmaceutical Sciences Kitasato University
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Satou Noriko
School Of Pharmaceutical Sciences Kitasato University
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Satou Takahiro
School Of Pharmaceutical Sciences Kitasato University
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Sakayanagi Masataka
School Of Pharmaceutical Sciences Kitasato University
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Takeda Kazuyoshi
Center For Advanced Technology Ebara Reseach Co. Ltd.
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Konda-Yamada Yaeko
School of Pharmaceutical Sciences, Kitasato University
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