Synthesis and Anti-tumor Activity of New Steroidal Nuclear Analogues of Aragusterol A
スポンサーリンク
概要
- 論文の詳細を見る
3α,7a-Dihydroxy-5-epiaragusterol A (3) was synthesized from bile acid (cholic acid) as a new steroidal nuclear analogue of antitumor marine steroid aragusterol A. 7α-Hydroxyaragusterol A (4) was also derived from xestokerol B. The in vitro anti-proliferative activity of each of these analogues toward KB cells as well as in vivo anti-tumor activity of 5-epiaragusterol A (2) previously synthesized by the authors and 3 were assessed.
- 公益社団法人日本薬学会の論文
- 2003-06-01
著者
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Shinohara Masakazu
School Of Pharmacy Tokyo University Of Pharmacy And Life Science
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Miyaoka Hiroaki
School Of Pharmacy Tokyo University Of Pharmacy And Life Science
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Yamada Y
School Of Pharmaceutical Sciences Kitasato University
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Yamada(konda) Yaeko
School Of Pharmaceutical Sciences Kitasato University
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MITOME Hidemichi
School of Pharmacy, Tokyo University of Pharmacy and Life Science
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Yamada Yasuji
School Of Pharmacy Tokyo University Of Pharmacy And Life Science
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MIYAOKA Hiroak
School of Pharmacy, Tokyo University of Pharmacy and Life Science
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Miyaoka H
School Of Pharmacy Tokyo University Of Pharmacy And Life Science
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Mitome H
School Of Pharmacy Tokyo University Of Pharmacy And Life Science
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Mitome Hidemichi
School Of Pharmacy Tokyo University Of Pharmacy And Life Science
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