Conformational Analysis of 19-Oxygenated Steroids with a 4-Ene or 2,4-Diene Structure, Potential Intermediates of Aromatase Reaction, with Semiempirical Molecular Orbital PM3 Calculations
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概要
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Conformational analysis of potent competitive inhibitors of aromatase, androst-4-enes 5,as well as 2,4-diene steroids 3,4,and 6 was carried out, using theoretical calculations, to determine the stereochemistry of their aromatase-catalyzed oxygenation. In the steroids examined, both the 19-alcohols and the 19-aldehydes favor the above-A ring conformation among the possible three in each. The results suggest that the 3-deoxy steroid 5a as well as the 2,4-diene steroids 4a and 6a would be oxygenated at C-19 by aromatase through the same stereomechanism as that involved in the androstenedione aromatization.
- 社団法人日本薬学会の論文
- 1995-05-15
著者
関連論文
- Conformational Analysis of 19-Oxygenated Steroids with a 4-Ene or 2,4-Diene Structure, Potential Intermediates of Aromatase Reaction, with Semiempirical Molecular Orbital PM3 Calculations
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