Effect of buthionine sulfoximine, an inhibitor of glutathione biosynthesis, on the selenium-induced lethality in mice.
スポンサーリンク
概要
- 論文の詳細を見る
The effect of buthionine sulfoximine (BSO), an inhibitor of glutathione (GSH) biosynthesis, on the selenium induced-lethality was examined in mice. A single injection of BSO (500 mg/kg, i.p.) markedly decreased the concentration of GSH in the liver after 5 hr. The acute lethality induced by selenium was greatly increased in BSO-treated mice. In contrast, the selenium induced-lethality decreased by pre- and post-treatments of cysteine (100 mg/kg, i.p.) in mice.
- 公益社団法人 日本薬理学会の論文
著者
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Sasaki Ken-ichi
Cancer Resarch Institute Tohoku College Of Pharmaceutical Sciences
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Takayanagi Giichi
Cancer Resarch Institute Tohoku College Of Pharmaceutical Sciences
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SASAKI Ken-ichi
Cancer Research Institute, Tohoku College of Pharmacy
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ISHIKAWA Masaaki
Cancer Research Institute, Tohoku College of Pharmacy
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- Effect of buthionine sulfoximine, an inhibitor of glutathione biosynthesis, on the selenium-induced lethality in mice.
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