Effect of Poly (ADP-ribose) Polymerase Inhibitors on Hypoadiponectinemia Caused by Chronic Blockade of Nitric Oxide Synthesis in Rats

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概要

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• Oxidant stress-induced activation of poly (ADP-ribose) polymerase (PARP) contributes to the pathogenesis of various cardiovascular diseases. Adiponectin is an adipocyte-derived anti-atherogenic protein. In the present study, we investigated the role of PARP in the development of hypoadiponectinemia caused by chronic blockade of nitric oxide synthesis with N^ω-nitro-L-arginine methyl ester (L-NAME) in rats. Decreased production of NO and increased production of O_2^- were observed in aortas from L-NAME-treated rats. Plasma adiponectin levels and adiponectin mRNA levels within adipose tissue were markedly decreased in L-NAME-treated rats. Concurrent administration of potent PARP inhibitors, INO-1001 or PJ34, with L-NAME did not restore plasma adiponectin levels or fat adiponectin mRNA levels. Thus, the cardiovascular protective effects of PARP inhibitors are not associated with adiponectin levels. Therefore, drugs which increase adiponectin levels may be beneficial alongside PARP inhibitors in the treatment of cardiovascular disease.

• 獨協医科大学の論文
• 2005-07-25

著者

• SATOH Hiroko

  Department of Chemistry, Gunma University

• Suzuki Kunihiro

  Departments of Histology, Cytology and Developmental Anatomy, Nihon University School of Dentistry a

• Hattori Yoshiyuki

  Department Of Biological Science Graduate School Of Science Hiroshima University

• Hattori Yoshiyuki

  獨協医科大学 医学部内分泌代謝内科学

• KASAI Kikuo

  Department of Endocrinology

• Kasai Kikuo

  Department Of Endocrinology And Metabolism Dokkyo University School Of Medicine

• KASE Hiroyuki

  Department of Astronomy, School of Science, The University of Tokyo

• Kase Hiroyuki

  Dokkyo Univ. School Of Medicine Tochigi Jpn

• Kase Hiroyuki

  Department Of Astronomy School Of Science The University Of Tokyo

• Kase Hiroyuki

  Department Of Endocrinology & Metabolism Dokkyo University School Of Medicine

• Suzuki Kunihiro

  Department Of Endocrinology & Metabolism Dokkyo University School Of Medicine

• Wang Xi

  Department of Endocrinology & Metabolism, Dokkyo University School of Medicine

• Iwata Chigusa

  Department of Endocrinology & Metabolism, Dokkyo University School of Medicine

• Iwata Chigusa

  Department Of Endocrinology & Metabolism Dokkyo University School Of Medicine

• Wang Xi

  Department Of Endocrinology & Metabolism Dokkyo University School Of Medicine

• Satoh Hiroko

  Department Of Chemistry Gunma University

• Wang Xi

  Department Of Cardiology Renmin Hospital Of Wuhan University

• SATOH Hiroko

  Department of Biochemical Toxicology, School of. Pharmaceutical Sciences, Showa University

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