A Morphological Study of the First Molars in Mice with High or Low Caries Susceptibility

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概要

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• The purpose of this study was to investigate whether the lesion of incipient caries was associated with morphological differences between the molars of C3H/HeJ and C57BL/6J mice. The caries scores for C57BL/6J and C3H/HeJ at 35 days old were 3.8±2.5 and 0±0 (mean±SD), respectively. The caries scores for C57BL/6J and C3H/HeJ at 49 days old were 42.4±8.3 and 4.2±2.4 (mean±SD), respectively. There was a 10-fold difference between C57BL/6J and C3H/HeJ in terms of caries progress. Incipient caries then appeared at the second fissure of lower M1. The central region of the second fissure of lower M1 in C57BL/6J was deeper and rougher than the same region in C3H/HeJ. The Ca/P ratios of the fissure for C57BL/6J and C3H/HeJ were 1.691±0.27 and 1.71±0.25 (mean±SD), respectively. The total data showed no significant difference between C57BL/6J and C3H/HeJ. In conclusion, it was found that incipient caries appeared at the second fissure of lower M1. Moreover, it is suggested that the morphology of the fissure as well as the immune responses may be responsible for the dental caries caused by stagnation of bacterial plaque.

• 日本大学の論文

著者

• Suzuki Kunihiro

  Departments of Histology, Cytology and Developmental Anatomy, Nihon University School of Dentistry a

• Maeda Takahide

  Department of Pediatric Dentistry, Nihon University School of Dentistry at Matsudo

• Maeda T

  Departments Of Pediatric Dentistry Research Institute Of Oral Science Nihon University School Of Den

• MATSUNE Kensuke

  Department of Pediatric Dentistry, Nihon University School of Dentistry at Matsudo

• SHIMIZU Kunihiko

  Department of Physics, Faculty of Engineering, Yokohama National University

• Uematsu Teruki

  Departments of Pediatric Dentistry, Nihon University School of Dentistry at Matsudo

• Nariyama Megumi

  Nihon University Graduate School of Dentistry at Matsudo, Pediatric Dentistry

• Matsunaga Rie

  Departments of Pediatric Dentistry, Research Institute of Oral Science, Nihon University School of D

• Matsunaga Rie

  Departments Of Pediatric Dentistry Research Institute Of Oral Science Nihon University School Of Den

• Uematsu Teruki

  Departments Of Pediatric Dentistry Nihon University School Of Dentistry At Matsudo

• Maeda Takahide

  Department Of Pediatric Dentistry Nihon University Graduate School Of Dentistry At Matsudo

• Suzuki Kunihiro

  Department Of Endocrinology & Metabolism Dokkyo University School Of Medicine

• Maeda Takahide

  Dep. Of Pediatric Dentistry Nihon Univ. Graduate School Of Dentistry At Matsudo

• Shimizu Kunihiko

  Departments Of Pediatric Dentistry Research Institute Of Oral Science Nihon University School Of Den

• Shimizu Kunihiko

  Department Of Internal Medicine Saiseikai Kanagawa-ken Hospital

• Matsune Kensuke

  Departments Of Pediatric Dentistry Research Institute Of Oral Science Nihon University School Of Den

• Matsune Kensuke

  Department Of Pediatric Dentistry Nihon University School Of Dentistry At Matsudo

• Nariyama Megumi

  Nihon University Graduate School Of Dentistry At Matsudo Pediatric Dentistry

• SHIMIZU KUNIHIKO

  Department of Chemical Engineering, Kobe University

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