Importance of Lipid Levels in Elderly Diabetic Individuals : Baseline Characteristics and 1-Year Survey of Cardiovascular Events
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概要
- 論文の詳細を見る
Background The respective incidences of ischemic heart and cerebrovascular disease (IHD, CVD) are high in diabetic individuals. Complications of dyslipidemia increase the risk, but direct evidence is limited, so a cohort prospective study (Japan-CDM) was conducted. Methods and Results The study group comprised 4,014 subjects with type 2 diabetes (1,936 women, 2,078 men; mean age 67.4±9.5 years) who were divided into dyslipidemic patients (79.1%) with or without medication (medicated, 50.9%; not medicated, 28.2%) and normo-lipidemic patients (20.9%). The incidence of IHD, CVD, arteriosclerosis obliterans (ASO), congestive heart failure (CHF) and death was assessed. IHD and CVD occurred in 0.82 and 0.67%, respectively, during the first year following registration. CHF, ASO and sudden death occurred in 0.27%, 0.12% and 0.12%, respectively. There was a significant statistical difference in the relation of elevated levels of high-density lipoprotein-cholesterol to lower rates of IHD and CVD. IHD and CVD in males were dependent on the level of low-density lipoprotein-cholesterol (LDL-C): 0.45%, 1.56%, 1.78%, 1.91% and 2.34% were observed in less than 2.11, 2.11-2.62, 2.63-3.15, 3.16-3.67, and more than 3.68 mol/L of LDL-C. In the lowest LDL-C group, death other than from vascular diseases was increased. Age, sex (male) and complicated hypertension increased the risk of events. Patients who were prescribed antihyperlipidemic agents suffered less events than patients who were not being treated, which suggests direct effects of therapy. Conclusion Strict lipid control may be effective for reducing the incidence of vascular events in Japanese diabetic individuals.
- 社団法人日本循環器学会の論文
- 2008-01-20
著者
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YAMADA Nobuhiro
Department of Internal Medicine, University of Tsukuba
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SONE Hirohito
Department of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba
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KUBOTA Kiyoshi
Department of Pharmacoepidemiology, Faculty of Medicine, University of Tokyo
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Watanabe Hiroshi
Department of Cardiology, Niigata City General Hospital
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Kawashima Seinosuke
Division Of Cardiovascular And Respiratory Medicine Kobe University Graduate School Of Medicine
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OHRUI Takashi
Department of Geriatric and Respiratory Medicine, Tohoku University School of Medicine
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HAYASHI Toshio
Department of Geriatrics, Nagoya University Graduate School of Medicine
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Iguchi Akihisa
Department of Geriatrics, Nagoya University Graduate School of Medicine
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Satoh Hiroshi
Division Of Cardiology Internal Medicine Iii Hamamatsu University School Of Medicine
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Kawashima Seinosuke
Division Of Cardiovascular And Respiratory Medicine Department Of Internal Medicine Kobe University
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Itoh Hideki
Tokyo Metropolitan Geriatric Hospital
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Nomura Hideki
Department Of Geriatrics Nagoya Kita Hospital
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Nomura Hideki
Department Of Cell Physiology Nagoya University Graduate School Of Medicine
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Hayashi Toshio
Department Of Gerontology Nagoya University Graduate School Of Medicine
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Hayashi Toshio
Department Of Geriatrics Nagoya University School Of Medicine
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Yokote Koutaro
Division Of Diabetes Metabolism And Endocrinology Department Of Internal Medicine Chiba University H
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Iguchi Akihisa
Department Of Gerontology Nagoya University Graduate School Of Medicine
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Iguchi Akihisa
Department Of Geriatrics Medicine In Growth And Aging Program In Health And Community Medicine Nagoy
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Sone Hirohito
Department Of Endocrinology & Metabolism Department Of Sports Medicine University Of Tsukuba
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UMEGAKI Hiroyuki
Department of Geriatrics, Nagoya University Graduate School of Medicine
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Hattori Yoshiyuki
Department Of Biological Science Graduate School Of Science Hiroshima University
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Hattori Yoshiyuki
Department Of Endocrinology And Metabolism Dokkyo University School Of Medicine
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Yoshizumi Masashi
Department of Cardiovascular Physiology, Hiroshima University Graduate School of Biomedical Sciences
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Yamada Nobuhiro
Department Of Internal Medicine Endocrinology And Metabolism Graduate School Of Comprehensive Human
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Yamada Nobuhiro
Department Of Chemistry And Chemical Engineering Yamagata University
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Hayashi Toshio
Department Of Geriatrics Nagoya University Graduate School Of Medicine
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Sone Hirohito
Department Of Nutrition Ochanomizu University
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Kubota Kiyoshi
Department Of Pharamacoepidemiology University Of Tokyo Faculty Of Medicine
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Watanabe Hiroshi
Clinical Pharmacology And Therapeutics Hamamatsu University School Of Medicine
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Umegaki Hiroyuki
Department Of Geriatrics Nagoya University Graduate School Of Medicine
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Ohrui Takashi
Department Of Geriatric Medicine Tohoku University School Of Medicine
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Ohrui Takashi
Department Of Geriatric And Respiratory Medicine Tohoku University Graduate School Of Medicine
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Yoshizumi Masashi
Department Of Cardiovascular Physiology Hiroshima University Graduate School Of Biomedical Sciences
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Watanabe Hiroshi
Department Of Clinical Pharmacology & Therapeutics Hamamatsu University School Of Medicine
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Hayashi Toshio
Department Of Bioldgy College Of General Education University Of Tokyo Komaba
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Watanabe Hiroshi
Department Of Applied Chemistry And Bioengineering Graduate School Of Engineering Osaka City Univers
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Satoh Hiroshi
Department Of Nutrition Ochanomizu University
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Hattori Yoshiyuki
Department of Endocrinology and Metabolism, Dokkyo University School of Medicine
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