Species Difference in the Contribution of T-Type Calcium Current to Cardiac Pacemaking as Revealed by R(-)-Efonidipine
スポンサーリンク
概要
- 論文の詳細を見る
The contribution of the T-type Ca2+ current to cardiac pacemaking was examined in isolated right atrial tissue from the mouse, guinea pig, and rabbit using a specific blocker, R(−)-efonidipine. At 10−6 M, R(−)-efonidipine produced negative chronotropy, which was prominent in the mouse and small but significant in the guinea pig. No effect was observed in the rabbit. Microelectrode recordings revealed that R(−)-efonidipine significantly prolongs the pacemaker (phase 4) depolarization of the sinoatrial-node action potential in the mouse and guinea pig. These results provide the first pharmacological evidence that the contribution of T-type Ca2+ current to cardiac pacemaking differs among experimental animal species.
- 社団法人 日本薬理学会の論文
- 2008-05-20
著者
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Nakamura Hideki
Department of Cardiovascular Medicine, Abashiri Kohsei General Hospital
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SUZUKI MARIKO
Department of Obstetrics and Gynecology, Faculty of Medicine, University of Yamanashi
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Nouchi Hideaki
Department Of Pharmacology Toho University Faculty Of Pharmaceutical Sciences
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TANAKA Hikaru
Department of Pharmacology, Toho University School of
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SHIGENOBU Koki
Department of Pharmacology, Toho University School of
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Tanaka Hikaru
Dep. Of Pharmacology Toho Univ. Fac. Of Pharmaceutical Sciences Jpn
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Tanaka H
Department Of Pharmacology Toho University School Of Pharmaceutical Sciences
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Shigenobu K
Department Of Pharmacology Toho University Faculty Of Pharmaceutical Sciences
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Shigenobu K
Department Of Pharmacology Toho University School Of Pharmaceutical Sciences
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Shigenobu Koki
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences The University Of Tokyo
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Namekata Iyuki
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Toho University
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Tsuneoka Yayoi
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Toho University
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Takahara Akira
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Toho University
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KOMIKADO Chisa
Department of Pharmacology, Toho University Faculty of Pharmaceutical Sciences
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Komikado Chisa
Department Of Pharmacology Toho University Faculty Of Pharmaceutical Sciences
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Tanaka Hikaru
Dep. Of Pharmacology Fac. Of Pharmaceutical Sciences Toho Univ.
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Tanaka Hikaru
Department Of Pharmacology Toho University Faculty Of Pharmaceutical Sciences
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Shigenobu Koki
Toho University School Of Pharmaceutical Sciences
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Tanaka Yoshio
Dep. Of Chemical Pharmacology Fac. Of Pharmaceutical Sciences Toho Univ.
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Takahara Akira
Department Of Internal Medicine National Kawatana Hospital
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Tanaka Yoshio
Department Of Chemical Pharmacology Toho University Faculty Of Pharmaceutical Sciences
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Tanaka Yoshio
Department Of Pharmacology Toho University Faculty Of Pharmaceutical Sciences
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Suzuki Mariko
Department Of Pharmacology Toho University Faculty Of Pharmaceutical Sciences
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Suzuki Mariko
Department Of Applied Physics Science University Of Tokoy
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Tanaka Hikaru
Department Of Internal Medicine Sasebo Senjyu Hospital
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Tsuneoka Yayoi
Department Of Molecular Biotechnology Graduate School Of Advanced Science Of Matter Hiroshima Univer
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Aikawa Tokiko
Department Of Pharmacology Toho University Faculty Of Pharmaceutical Sciences
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Namekata Iyuki
Department Of Pharmacology Toho University Faculty Of Pharmaceutical Sciences
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Tanaka Hikaru
Department Of Internal Medicine Hirosaki Municipal Hospital
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Namekata Iyuki
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Toho University
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Tanaka Hikaru
Department of Endocrinology and Metabolism, Hirosaki University
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Takahara Akira
Department of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Toho University
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