Effects of a Novel Vesamicol Receptor Ligand, m-(Iodobenzyl)trozamicol, on the Canine Isolated, Blood-Perfused Atrioventricular Node Preparation
スポンサーリンク
概要
- 論文の詳細を見る
m-(Iodobenzyl)trozamicol(MIBT)is a recently discovered vesamicol analgoue.It has been shown that radiolabelled [125I]MIBT can be used as a marker of cholinergic innervation in the heart as well as in the brain.The purpose of this study was to analyze the direct effects of MIBT on the atrioventricular and intraventricular conduction in addition to the coronary blood flow using the canine isolated, blood-perfused atrioventricular node preparation.Intracoronary administration of MIBT suppressed the atrioventricular and intraventricular conduction, while it increased the coronary blood flow.The effect and duration of action on the intraventricular conduction was less pronounced compared with other effects.Moreover, the doses of MIBT needed to cause negative dromotropic and coronary vasodilator effects in this study was much greater than those needed for imaging the cardiac cholinergic innervation.Pretreatment of the preparations with a muscarinic receptor antagonist, atropine, did not block these effects of MIBT, suggesting that MIBT may possess muscarinic receptor-independent ion channel activity in the cardiac conduction system and coronary arteries.
- 社団法人 日本薬理学会の論文
- 2000-02-01
著者
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HASHIMOTO Keitaro
Department of Pharmacology, Interdisciplinary Graduate School of Medicine and Engineering, Universit
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Sugiyama Atsushi
Department of Pharmacology, School of Medicine, Toho University, Japan
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Lurie Keith
Cardiac Arrhythmia Center Department Of Medicine University Of Minnesota
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Takahara Akira
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Toho University
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Takahara Akira
Department Of Internal Medicine National Kawatana Hospital
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Sugiyama Atsushi
Department Of Pharmacology Yamanashi Medical University
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Takehana Shunji
Fuji Biomedix Co. Ltd.
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EFANGE Simon
Department of Radiology, University of Minnesota
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TAKEHANA Shunji
Department of Pharmacology, Yamanashi Medical University
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Efange Simon
Department Of Radiology University Of Minnesota
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Hashimoto Keitaro
Department Of Pharmacology Interdisciplinary Graduate School Of Medicine And Engineering University
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Hashimoto Keitaro
Department Of Pharmacology Interdisciplinary Graduate School Of Medicine And Engineering University
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Sugiyama Atsushi
Department Of Pharmacology. University Of Yamanashi Yamanashi Research Center Of Cliniacl Pharmacolo
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Sugiyama Atsushi
Department Of Chemistry College Of Science Rikkyo University
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Aikawa Tokiko
Department Of Pharmacology Toho University Faculty Of Pharmaceutical Sciences
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Sugiyama Atsushi
Department Of Pharmacology School Of Medicine Toho University
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HASHIMOTO Keitaro
Department of Phamacology, Yamanashi Medical University
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Sugiyama Atsushi
Department of Biotechnology, Faculty of Engineering, Kansai University
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Takahara Akira
Department of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Toho University
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