Blocking Effect of NIP-142 on the KCNQ1/KCNE1 Channel Current Expressed in HEK293 Cells
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概要
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We examined the effect of NIP-142, a benzopyran compound with terminating effect on experimental atrial arrhythmia, on the KCNQ1/KCNE1 channel, which underlies the slow component of the cardiac delayed rectifier potassium channel (IKs). NIP-142, as well as chromanol 293B, showed concentration-dependent blockade of the current expressed in HEK293 cells; the EC50 value of NIP-142 and chromanol 293B for the inhibition of tail current was 13.2 μM and 4.9 μM, respectively. These results indicate that NIP-142 has blocking effect on the KCNQ1/KCNE1 channel current.
著者
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Suzuki Takeshi
Department of Internal Medicine, Nippon Medical School
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Takahashi Tetsuo
Department Of Cardiology Yokohama Municipal Citizen's Hospital
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Iida-tanaka Naoko
Department Of Food Science Otsuma Women's University
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TANAKA Hikaru
Department of Pharmacology, Toho University School of
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Namekata Iyuki
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Toho University
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Tsuruoka Noriko
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Toho University
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Tsuneoka Yayoi
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Toho University
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Matsuda Tomoyuki
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Toho University
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Takahara Akira
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Toho University
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Tanaka Yoshio
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Toho University
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Tanaka Hikaru
Department Of Pharmacology Toho University Faculty Of Pharmaceutical Sciences
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Tanaka Yoshio
Dep. Of Chemical Pharmacology Fac. Of Pharmaceutical Sciences Toho Univ.
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Toyoda Yoshihiro
Sagami Research Laboratory Wakamoto Pharmaceutical Co. Ltd.
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Takahara Akira
Department Of Internal Medicine National Kawatana Hospital
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Suzuki Takeshi
Department Of Anatomy And Cell Biology Gunma University Graduate School Of Medicine
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Tanaka Yoshio
Department Of Chemical Pharmacology Toho University Faculty Of Pharmaceutical Sciences
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Tanaka Yoshio
Department Of Pharmacology Toho University Faculty Of Pharmaceutical Sciences
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Tanaka Hikaru
Department Of Internal Medicine Sasebo Senjyu Hospital
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Matsuda Tomoyuki
Department Of Anesthesiology And Anatomy And Neurobiology Kyoto Prefectural University Of Medicine
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Takahashi Tetsuo
Department Of Applied Biochemistry Institute Of Glycotechnology Tokai University
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Tsuneoka Yayoi
Department Of Molecular Biotechnology Graduate School Of Advanced Science Of Matter Hiroshima Univer
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Namekata Iyuki
Department Of Pharmacology Toho University Faculty Of Pharmaceutical Sciences
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Tanaka Yoshio
Department Of Applied Chemistry Faculty Of Engineering Yokohama National University
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Suzuki Takeshi
Department Of Allergy And Rheumatology Graduate School Of Medicine University Of Tokyo
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Namekata Iyuki
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Toho University
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Takahashi Tetsuo
Department of Biophysical Chemistry, Faculty of Pharmaceutical Sciences, Toho University
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Tanaka Hikaru
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Toho University
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Tanaka Hikaru
Department of Endocrinology and Metabolism, Hirosaki University
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Iida-Tanaka Naoko
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Toho University
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Iida-Tanaka Naoko
Department of Biochemistry, Teikyo University School of Medicine
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Takahara Akira
Department of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Toho University
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Suzuki Takeshi
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Toho University
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