Evaluation of Effects of Antiarrhythmics on Ventricular Premature Contraction : Pharmacology and Clinical Evaluation of Antiarrhythmic Drugs
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概要
- 論文の詳細を見る
Although subjective symptoms and brief recording of ECG have been used for an efficacy evaluation of new antiarrhythmics on ventricular premature contraction (VPC), incidence of subjective complaints in VPC was under 25% and number of VPC for 3 min did not correlate enough to those for 24 hours, indicating these parameters are not appropriate for such a trial. Number of VPC automatically counted by DECG (continous ECG recording for 24 hours) showed high accuracy, while day to day variation of VPC arose as the next problem. While cases of more than about 7,000/day showed very little day to day variation, cases of less than about 1,000/day had poor reproducibility, indicating that the former group can be used for the trials of new antiarrhythmics, but not the latter group. For cases with medium magnitude of VPC variation, DECG should be recorded twice during the period without drug administration and application of the paired t-test for number of VPC in each corresponding hour may bring a good evaluation.
- 社団法人日本循環器学会の論文
- 1983-01-20
著者
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Saitoh Tsutomu
First Department Of Internal Medicine Nippon Medical School
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SUZUKI TAKESHI
The First Department of Internal Medicine, Nippon Medical School
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Otsu Fumio
Department of Internal Medicine, Nippon Medical School
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Suzuki Takeshi
Department of Internal Medicine, Nippon Medical School
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Nejima Jun
Department of Internal Medicine, Nippon Medical School
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Nejima Jun
Intensive And Cardiac Care Unit Nippon Medical School Hospital
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Hayakawa Hirokazu
The First Department Of Medicine Nippon Medical School
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Hayakawa Hirokazu
The First Department Of Internal Medicine Nippon Medical School
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Saito Tsutomu
The First Department Of Internal Medicine Nippon Medical School
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Hayakawa Hirokazu
Department Of Physiological Laboratory Nippon Medical School
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Otsu Fumio
Department Of Internal Medicine Nippon Medical School
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SATO Tadanobu
Department of Industrial Chemistry, Faculty of Engineering, Seikei University
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IIDA NOBUKO
Department of Internal Medicine, Nippon Medical School
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Saito Tsutomu
Department Of Internal Medicine Nippon Medical School
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Otsu Fumio
Dept Of Intern. Med Nippon Med School Tokyo
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Nejima Jun
Protect (prospective Trial Of Cardioprotective Effect Of Carperitide Treatment) Study Group
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Iida Nobuko
1st Dept Of Intern Med Nippon Medical School
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Suzuki Takeshi
Department Of Anatomy And Cell Biology Gunma University Graduate School Of Medicine
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Nejima Jun
Department Of Intensive Care Medicine Nippon Medical School
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Hayakawa Hirokazu
Department Of Cardiology Nippon Medical School
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Iida Nobuko
1st Dept. Of Int. Med. Nippon Medical School
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Nejima Jun
日本医科大学 集中治療
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Suzuki Takeshi
The First Department Of Internal Medicine Nippon Medical School
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Saito Tsutomu
1st Department Of Internal Medicine Nippon Medical School
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Suzuki Takeshi
Department Of Allergy And Rheumatology Graduate School Of Medicine University Of Tokyo
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