Enhancement of the Serotonin-Mediated Acetylcholine Release by Repeated Desmethylimipramine Treatment in the Hippocampus of Freely Moving Rats
スポンサーリンク
概要
- 論文の詳細を見る
A possible involvement of serotonin-mediated cholinergic activation in the antidepressant effect of desmethylimipramine (DMI) was investigated by determination of the effects of a single or repeated DMI administration on acetylcholine (ACh) release in the hippocampus using an in vivo microdialysis technique and a radioimmunoassay for ACh. Rats were administered DMI (10 mg/kg, i.p.) acutely or repeatedly for 21 days. A single or repeated DMI administration did not cause any significant effects on the basal ACh release compared with the respective controls. Atropine perfusion in the acutely DMI-treated or control rats increased the ACh release to the same degree. In repeatedly DMI-treated rats, serotonin (5-HT) (1 to 10 μM) perfusion enhanced significantly the ACh release. However, 5-HT in acutely DMI-treated rats enhanced significantly the ACh release only at 10 μM. 5-HT did not cause any changes in ACh release in control rats. Hippocampal 5-HT content of acutely DMI-treated rats was significantly higher than that of saline-treated control rats, while no difference was observed between the repeatedly DMI- and saline-treated rats. These findings suggest, for the first time, that DMI induced a facilitation of cholinergic neurotransmission in the rat hippocampus through the activation of 5-HT-receptor function.
- 社団法人 日本薬理学会の論文
- 1999-08-01
著者
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Suzuki Takeshi
Department of Internal Medicine, Nippon Medical School
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Fujii Takeshi
Department of Cardiology, Nihon University Surugadai Hospital
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KAWASHIMA Koichiro
Department of Mechanical Engineering, Nagoya Institute of Technology
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OHBA Shigeru
Department of Chemistry, Keio University
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Ohba Shigeru
Department Of Applied Physics Nagoya University:the Institute For Solid State Physics The University
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Ohba Shigeru
Department Of Pharmacology Kyoritsu College Of Pharmacy
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Suzuki Takeshi
Department Of Anatomy And Cell Biology Gunma University Graduate School Of Medicine
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Kawashima K
Nagoya Inst. Of Technol. Nagoya Jpn
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NAKAI Katsuhiko
Department of Pharmacology, Kyoritsu College of Pharmacy
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FUJIMOTO Kazuko
Department of Pharmacology, Kyoritsu College of Pharmacy
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藤井 健志
共立薬大 薬
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Kawashima Koichiro
Department Of General Education Nagoya University
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Nakai Katsuhiko
Department Of Pharmacology Kyoritsu College Of Pharmacy
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Fujii T
Department Of Pharmacology Kyoritsu College Of Pharmacy
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Fujimoto Kazuko
Department Of Phamacology Kyoritsu College Of Pharmacy
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Suzuki Takeshi
Department Of Pharmacology Kyoritsu College Of Pharmacy
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Fujii Takeshi
Department Of Applied Biological Science Faculty Of Science And Technology Science University Of Tok
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Suzuki Takeshi
Department Of Allergy And Rheumatology Graduate School Of Medicine University Of Tokyo
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OHBA SHIGERU
Deparment of Biology, Faculty of Science, Tokyo Metropolitan University
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KAWASHIMA Koichiro
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, University of Tokyo
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