Mechanisms of Chronic Nicotine Treatment–Induced Enhancement of the Sensitivity of Cortical Neurons to the Neuroprotective Effect of Donepezil in Cortical Neurons
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概要
- 論文の詳細を見る
We have previously shown that chronic donepezil treatment induces nicotinic acetylcholine receptor up-regulation and enhances the sensitivity of the neurons to the neuroprotective effect of donepezil. Further analyses revealed that the nicotinic receptor is involved in this enhancement. In this study, we examined whether nicotinic receptor stimulation is sufficient to make neurons more sensitive to donepezil. We treated primary cultures of rat cortical neurons with nicotine and confirmed that chronic nicotine treatment induced nicotinic receptor up-regulation and made the neurons more sensitive to the neuroprotective effects of donepezil. Analyses with receptor antagonists and kinase inhibitors revealed that the effects of chronic nicotine treatment are mediated by nicotinic receptors and their downstream effectors including phosphatidylinositol 3-kinase. In contrast to chronic donepezil treatment that enhanced the level of nicotine-induced Ca2+ influx, chronic nicotine treatment did not significantly alter the level of Ca2+ influx.
- 社団法人 日本薬理学会の論文
著者
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Izumi Yasuhiko
京都大学 薬学研究科薬品作用解析学分野
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Izumi Yasuhiko
京都大学 薬学研究科薬品作用解析学
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Izumi Yasuhiko
Department Of Pharmacology Graduate School Of Pharmaceutical Sciences Kyoto University
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Kume Toshiaki
京都大学 薬学研究科生体機能解析学
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Kume Toshiaki
京都大学 薬学研究科薬品作用解析学分野
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Kume Toshiaki
京都大学 薬学研究科薬品作用解析学
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Kume Toshiaki
同志社女子大学 医療薬学科薬理学
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Kume Toshiaki
Department Of Pharmaceutical Science Kyoto University Graduate School Of Pharmacology
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Takada-takatori Yuki
京都大学 薬学研究科薬品作用解析学
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Akaike Akinori
Department Of Pharmacology Graduate School Of Pharmaceutical Sciences Kyoto University
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Fujii Takeshi
Department of Cardiology, Nihon University Surugadai Hospital
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Kume Toshiaki
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Kyoto University
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Takada-Takatori Yuki
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Doshisha Women’s College, Japan
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Niidome Tetsuhiro
Department of Neuroscience for Drug Discovery Research, Graduate School of Pharmaceutical Sciences,
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Sugimoto Hachiro
Department of Neuroscience for Drug Discovery Research, Graduate School of Pharmaceutical Sciences,
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Akaike Akinori
Department Of Pharmaceutical Science Kyoto University Graduate School Of Pharmacology
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Sugimoto Hachiro
Department Of Neuroscience For Drug Discovery Graduate School Of Pharmaceutical Sciences Kyoto Unive
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Niidome Tetsuhiro
Department Of Neuroscience For Drug Discovery Graduate School Of Pharmaceutical Sciences Kyoto Unive
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Tochikawa Yoshinaga
Institute Of Research And Development Fujimoto Pharmaceutical Corporation
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Takada-takatori Yuki
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Doshisha Women's College
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Fujii Takeshi
Department Of Applied Biological Science Faculty Of Science And Technology Science University Of Tok
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Kume T
Department Of Pharmacology Graduate School Of Pharmaceutical Sciences Kyoto University
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Sugimoto Hachiro
Department of Neuroscience for Drug Discovery Research, Graduate School of Pharmaceutical Sciences, Kyoto University, Japan
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Izumi Yasuhiko
Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Japan
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Takada-Takatori Yuki
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Doshisha Women's College, Japan
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Niidome Tetsuhiro
Department of Neuroscience for Drug Discovery Research, Graduate School of Pharmaceutical Sciences, Kyoto University, Japan
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Fujii Takeshi
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Doshisha Women's College, Japan
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Akaike Akinori
Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Japan
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Akaike Akinori
Department of Neuropharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University
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