Non-neuronal Neurotransmitters and Neurotrophic Factors in Amniotic Epithelial Cells: Expression and Function in Humans and Monkey
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概要
- 論文の詳細を見る
Human amniotic epithelial cells (HAEC) are formed from epiblasts on the 8th day after fertilization. Because they lack major histocompatibility complex (MHC) antigen, human amniotic tissue transplantation has been used for allotranplantation to treat patients with lysosomal diseases. We have provided evidence that HAEC have multiple functions such as synthesis and release of acetylcholine (ACh) and catecholamine (CA) as well as expressing mRNA coding for dopamine receptors and dopamine (DA) transporter (DAT). On the other hand, we showed that monkey amniotic epithelial cells (MAEC) synthesize and release CA and posses DA receptors and DAT. Detection of muscarinic actylcholine receptors indicates the presence of an autocrine mechanism in HAEC. Recently, we found that HAEC have neurotrophic function in conditioned medium from HAEC, indicating the presence of a novel neurotrohpic factor that is synthesized and released from HAEC. The amniotic membrane may have a significant role in supplying neurotrophic factors as well as neurotransmitters to the amniotic fluid, suggesting an important function in the early stages of neural development of the embryo. This review will focus on the neuropharmacological aspects of HAEC and MAEC in relation to the physiology of amniotic membrane.
- 社団法人 日本薬理学会の論文
- 2001-01-01
著者
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Fujii Takeshi
Department of Cardiology, Nihon University Surugadai Hospital
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KAWASHIMA Koichiro
Department of Mechanical Engineering, Nagoya Institute of Technology
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UCHIDA Saiko
Department of Inherited Metabolic Disease, National Institute of Neuroscience, National Center of Ne
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SAKURAGAWA Norio
Department of Inherited Metabolic Disease, National Institute of Neuroscience, National Center of Ne
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Uchida S
Department Of Inherited Metabolic Diseases National Institute Of Neuroscience National Center Of Neu
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Uchida Saiko
Department Of Inherited Metabolic Disease National Institute Of Neuroscience National Center Of Neur
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Sakuragawa N
Department Of Inherited Metabolic Diseases National Institute Of Neuroscience National Center Of Neu
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Sakuragawa Norio
Department Of Inherited Metabolic Disease National Institute Of Neuroscience National Center Of Neur
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ELWAN Mohamed
Department of Inherited Metabolic Diseases, National Institute of Neuroscience, National Center of N
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Elwan Mohamed
Department Of Inherited Metabolic Diseases National Institute Of Neuroscience National Center Of Neu
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藤井 健志
共立薬大 薬
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Kawashima Koichiro
Department Of General Education Nagoya University
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Fujii T
Department Of Pharmacology Kyoritsu College Of Pharmacy
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Fujii Takeshi
Department Of Applied Biological Science Faculty Of Science And Technology Science University Of Tok
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KAWASHIMA Koichiro
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, University of Tokyo
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