ACUTE AND SUBCHRONIC EFFECTS OF BOMETOLOL ON BLOOD PRESSURE IN HYPERTENSIVE RATS
スポンサーリンク
概要
- 論文の詳細を見る
Bometolol is a cardiospecific β-adrenergic blocking drug. The effect on blood pressure was determined in hypertensive rats in acute and subchronic experiments. In acute experiment bometolol, 10-30 mg/kg, p.o., was given to spontaneously hypertensive rats ; deoxycorticosterone and salt hypertensive rats ; and two kidney, one clip hypertensive rats. Blood pressure was determined continuously for 8 h and after 24 h in unanesthetized condition. The blood pressure lowered by bometolol was dose-dependent in three types of hypertension. In subchronic experiment, bometolol at a dose of 10-30 mg/kg or 100-300 mg/kg, p.o., were given for 5 weeks to deoxycorticosterone and salt hypertensive rats ; and two kidney, one clip hypertensive rats. Bometolol did not show antihypertensive effect in either type of hypertension, although bometolol decreased heart rate dose-dependently. Bometolol treatment at the above doses decreased plasma renin activity, heart and kidney weights, and incidence of vascular lesion in either hypertensive rat. Toxic symptom was seen 3 days after bometolol treatment of 300 mg/kg in deoxycorticosterone and salt hypertensive rats.
- 公益社団法人日本薬学会の論文
著者
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Watanabe Yoshiteru
Department of Pharmaceutics and Biopharmaceutics, Showa Pharmaceutical University
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KAWASHIMA Koichiro
Department of Mechanical Engineering, Nagoya Institute of Technology
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Kawashima Koichiro
Department Of Pharmacology Jichi Medical School
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Watanabe Yoshiteru
Department Of Pharmaceutics And Biopharmaceutics Showa Pharmaceutical University
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Watanabe Yoshiteru
Department Of Pharmacology Jichi Medical School
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WATANABE TAKUSHIX.
Department of Pharmacology, Jichi Medical School
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HASEGAWA YUKIO
Department of Pharmacology, Jichi Medical School
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KUDO YOSHITAKA
Department of Pharmacology, Jichi Medical School
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SOKABE HIROFUMI
Department of Pharmacology, Jichi Medical School
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Hasegawa Yukio
Department Of Pharmacology Jichi Medical School
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Kudo Yoshitaka
Department Of Pharmacology Jichi Medical School
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Sokabe Hirofumi
Department Of Pharmacology Jichi Medical School
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Sokabe Hirofumi
Department Of Parmacology Toho University Shool Of Medicine
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Watanabe Takushix.
Department Of Pharmacology Jichi Medical School
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Kawashima Koichiro
Department Of General Education Nagoya University
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SOKABE Hirofumi
Departine rt of Pharmacology, Jichi Medical School
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KAWASHIMA Koichiro
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, University of Tokyo
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